Comparative study of intracisternal kaolin injection techniques to induce congenital hydrocephalus in fetal lamb

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Soner DuruJose L Peiro

Abstract

Kaolin (aluminum silicate) has been used to generate hydrocephalus by direct cisterna magna injection in animal models. The aim of the present study is to compare which method of Kaolin injection into fetal cisterna magna is feasible, safer, and more effective to induce hydrocephalus in fetal lambs. Twenty-five well-dated pregnant ewes at gestational 85-90 days (E85-90) were used to compare three different kaolin injection puncture techniques into the fetal cisterna magna. Group 1, ultrasound guidance in a maternal percutaneous transabdominal (TA); group 2, without opening the uterus in a transuterine (TU) technique; group 3, by occipital direct access after exteriorizing fetal head (EFH); and group 4, control group, was normal fetal lambs without injection. The fetal lambs were assessed using lateral ventricle diameter ultrasonographic measurements prior the kaolin injection and on the subsequent days. We analyzed the effectivity, mortality, and fetal losses to determine the best technique to create hydrocephalus in fetal lamb. After fetal intracisternal kaolin (2%, 1mL) injection, lateral ventricle diameters increased progressively in the three different interventional groups compared with the normal values of the control gro...Continue Reading

References

Dec 1, 1975·Developmental Medicine and Child Neurology·R T Johnson
Jul 1, 1969·Journal of Neurosurgery·H WisniewskiR D Terry
Nov 1, 1984·Journal of Neurosurgery·J Gonzalez-DarderJ L Barcia-Salorio
Jan 1, 1984·Journal of Neurosurgery·M S EdwardsD H Chinn
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Jun 30, 2005·Seminars in Fetal & Neonatal Medicine·Tejas S Mehta, Deborah Levine
Nov 1, 1932·Proceedings of the National Academy of Sciences of the United States of America·F H Clark
Mar 1, 1947·Journal of Neurosurgery·F D INGRAHAMD D MATSON

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Citations

Nov 9, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Smruti K PatelFrancesco T Mangano
Jul 1, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jose L Peiro, Mateus Dal Fabbro
May 27, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Maria Florencia VarelaMarc Oria

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