Comparative study of inverted internal limiting membrane (ILM) flap and ILM peeling technique in large macular holes: a randomized-control trial

BMC Ophthalmology
Naresh Babu KannanKim Ramasamy

Abstract

The anatomical success rate of macular hole surgery ranges around 93-98%. However, the prognosis of large macular holes is generally poor. The study was conducted to compare the anatomical and visual outcomes of Internal Limiting Membrane (ILM) peeling vis-a-vis inverted ILM flap for the treatment of idiopathic large Full-Thickness Macular Holes (FTMH). This was a prospective randomized control trial. The study included patients with idiopathic FTMH, with a minimum diameter ranging from 600 to 1500 μm. The patients were randomized into Group A (ILM peeling) and Group B (inverted ILM flap). The main outcome measures were anatomical and visual outcome at the end of 6 months. Anatomical success was defined as flattening of macular hole with resolution of the subretinal cuff of fluid and neurosensory retina completely covering the fovea. There were 30 patients in each group. The mean minimum diameters in Group A and B were 759.97 ± 85.01 μm and 803.33 ± 120.65 μm respectively (p = 0.113). The mean base diameter in group A and B was 1304.50 ± 191.59 μm and 1395.17 ± 240.56 μm respectively (p = 0.112). The anatomical success rates achieved in Group A and B were 70.0 and 90.0% respectively (p = 0.125). The mean best-corrected visual a...Continue Reading

References

Feb 3, 2000·The British Journal of Ophthalmology·R A ScottZ J Gregor
Jul 27, 2001·Ophthalmology·W E SmiddyG Cordahi
Jan 25, 2002·Archives of Ophthalmology·Michael S IpCarmen A Puliafito
Mar 27, 2002·The British Journal of Ophthalmology·S UllrichA Kampik
Jan 8, 2003·Ophthalmology Clinics of North America·Michael LandolfiNeelakshi Bhagat
May 9, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S WolfU E K Schnurrbusch
Jul 26, 2003·The British Journal of Ophthalmology·S W KangD-I Ham
Jun 10, 2004·Retina·Lori A StecMorton S Cox
Apr 14, 2007·Clinical & Experimental Ophthalmology·Christos HaritoglouAnselm Kampik
Apr 29, 2008·The British Journal of Ophthalmology·J M Ruiz-MorenoP Amat
Jun 15, 2010·Ophthalmology·Zofia MichalewskaJerzy Nawrocki
Dec 4, 2012·Indian Journal of Ophthalmology·Dhananjay ShuklaSoubhya B Thayyil
Apr 11, 2013·Indian Journal of Ophthalmology·Dhananjay Shukla
Nov 12, 2013·Indian Journal of Ophthalmology·Prabhushanker Mahalingam, Kumar Sambhav
Sep 19, 2014·Indian Journal of Ophthalmology·Mahesh P ShanmugamDivyansh Mishra
May 23, 2015·The British Journal of Ophthalmology·Jay ChhablaniAditya Sudhalkar
Jun 4, 2016·BMC Ophthalmology·Naresh B KannanKim Ramasamy
Sep 3, 2016·International Journal of Ophthalmology·Mitali KhodaniJay Chhablani
Oct 4, 2017·Investigative Ophthalmology & Visual Science·Yusuke ShiodeFumio Shiraga
Feb 27, 2018·International Journal of Retina and Vitreous·Raul Velez-MontoyaSergio E Hernandez-Da Mota
Mar 14, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chufeng Gu, Qinghua Qiu
Apr 20, 2018·Acta Ophthalmologica·Toshifumi YamashitaUNKNOWN writing committee of Japan-Clinical Retina Research Team (J-CREST)

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Citations

Mar 27, 2020·Ophthalmic Surgery, Lasers & Imaging Retina·Raquel Esteves MarquesCarlos Marques-Neves
Oct 24, 2019·International Journal of Retina and Vitreous·Giancarlo SborgiaGiovanni Alessio
Apr 9, 2019·Journal of Ophthalmology·Fabrizio GiansantiStanislao Rizzo
Jun 14, 2019·Journal of Ophthalmology·Guzel BikbovaKeisuke Mori
Jan 30, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nathalie BleidißelMathias Maier
Dec 10, 2020·International Journal of Retina and Vitreous·Sergio Rojas-JuárezRaul Velez-Montoya
Aug 20, 2021·Clinical Ophthalmology·Nisa SilvaAngelina Meireles
Sep 4, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jih-Pin Lin, Chung-May Yang
Jan 16, 2020·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Ferdinando BottoniGrazia Pertile
Sep 9, 2021·Ophthalmology and Therapy·Jessica L Cao, Peter K Kaiser
Dec 16, 2021·Ophthalmic Surgery, Lasers & Imaging Retina·Deependra Vikram SinghAwaneesh Upadhyay

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