Comparative study of macro- and microsurgical extrahepatic cholestasis in the rat

Microsurgery
Maria Angeles AllerJaime Arias

Abstract

The long-term (5-week) evolution of two experimental models of extrahepatic cholestasis, i.e., macrosurgical by bile duct ligation (n = 20) and microsurgical by biliary tract resection (n = 13), is studied. All cholestatic animals showed jaundice, choluria, and portosystemic collateral circulation. Macrosurgical cholestasis causes greater hepatosplenomegaly, hilar biliary pseudocysts, and ascites. Microsurgical extrahepatic cholestasis occurs with a lower degree of hepatosplenomegaly as well as with serum increase (P < 0.001) of gamma-GT and alkaline phosphatase. The bile ductular proliferation in the four hepatic lobes is very intense (P < 0.001) in both experimental models. The differences between both experimental models may be considered secondary to the increase of the predisposition to infection in rats with bile duct ligation, that complicates their evolution. The microsurgical cholestasis model could be useful in studying cholestasis secondary to biliary atresia.

References

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Citations

Sep 26, 2007·Journal of Translational Medicine·María-Angeles AllerJaime Arias
Nov 15, 2007·Theoretical Biology & Medical Modelling·María-Angeles AllerJaime Arias
Nov 19, 2008·Fibrogenesis & Tissue Repair·María-Angeles AllerJaime Arias
Aug 3, 2012·World Journal of Hepatology·Maria-Angeles AllerJaime Arias
Jul 31, 2009·European Journal of Gastroenterology & Hepatology·Maria-Angeles AllerJaime Arias
Dec 25, 2009·The Journal of Surgical Research·José García-DominguezJaime Arias
Jul 15, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Maria-Angeles AllerJaime Arias
Jun 19, 2008·Microsurgery·Fernando Sánchez-PatánJaime Arias
Jan 31, 2014·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jen-Bin WangTaiwai Chin
Jun 4, 2015·Food & Function·Andrej BartaOlga Pechánová
Oct 25, 2016·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Belgin KaranAhmet Muhtesem Agildere
Nov 1, 2006·World Journal of Gastroenterology : WJG·Juan-G AbraldesJuan-Carlos García-Pagán
Oct 9, 2019·Archives of Medical Research·Maria-Angeles AllerJaime Arias

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