Comparative study of metallic biomaterials toxicity: a histochemical and immunohistochemical demonstration in mouse spleen

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Maria Eduarda FerreiraGraça Simões de Carvalho

Abstract

Metallic biomaterials available for orthopaedic purposes become essential to perform important physical activities, due to their low cost and excellent mechanical properties. In addition, they are frequently used in dentistry. However, corrosion phenomena of such devices are the main problems resulting in subsequent spreading of the elements through the whole body via lymph and blood. The spleen is the most important lymphoid organ and the only one included in the blood circulation. Thus, the aim of this study was to evaluate the short-term effects on spleen tissues of heavy metals released from stainless steel and Cr-Co-Mo alloys, as well as from titanium, at histochemical and immunohistochemical levels. For this purpose, metallic suspensions were obtained by electrochemical dissolution of the mentioned biomaterials: stainless steel (Fe 490 mg/L, Cr 224 mg/L, Ni 150 mg/L), Cr-Co-Mo (Cr 200 mg/L, Co 375 mg/L), and titanium (400 mg/L). Then 0.5 ml of each solution was subcutaneously administered to male Charles River mice each 72 hours during 30 days. Cryostat sections of the spleen from all groups were submitted to routine staining with haematoxylin/eosin, peroxidase detection by 3-3' diaminobenzidine (DAB), and alkaline phosph...Continue Reading

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Citations

Mar 24, 2006·Journal of Materials Science. Materials in Medicine·Lucio MontanaroCarla Renata Arciola
Jan 30, 2013·Journal of Biomedical Materials Research. Part a·Wilhelm HofstetterErnst B Hunziker
Feb 14, 2012·Journal of Applied Toxicology : JAT·Ioannis PolyzoisStamatios Theocharis
Dec 4, 2012·Journal of Biomedical Materials Research. Part a·Qiuming PengYongjun Tian
Apr 30, 2008·The Annals of Thoracic Surgery·Pam M KimballVigneshwar Kasirajan
Dec 1, 2011·Food Chemistry·Gian Carlo TenoreEttore Novellino
Sep 24, 2010·Acta Orthopaedica·Anton H HosmanDanielle Neut
Aug 4, 2005·Journal of Biomedical Materials Research. Part a·Clayton N KraftPeter H Pennekamp
Jun 2, 2007·The Journal of Bone and Joint Surgery. British Volume·G M KeeganC P Case
Jun 24, 2008·Critical Reviews in Clinical Laboratory Sciences·William Cruz-Munoz, Rama Khokha
Jan 30, 2014·Cancers·Antonietta Rosella Farina, Andrew Reay Mackay
Aug 30, 2017·International Journal of Oncology·G A CardamaD E Gomez
May 8, 2014·Food Science & Nutrition·Feng-Mei ZhuJun Li
Nov 13, 2007·Journal of Agricultural and Food Chemistry·Sumiko NakamuraKen'ichi Ohtsubo

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