Comparative study of muscle regeneration following cardiotoxin and glycerol injury

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
Mohamed A A MahdyTakanori Nishimura

Abstract

In the present study, we examined muscle regeneration following two types of chemical injuries, cardiotoxin (CTX) and glycerol, in order to compare their effect on the morphological characteristics during muscle regeneration, in addition we studied the structural changes of the intramuscular connective tissue (IMCT) during the regeneration process, by scanning electron microscopy (SEM) after digestion of the cellular elements of the muscle with sodium hydroxide. Tibialis anterior (TA) muscles of adult male mice were injected either with CTX or glycerol. Muscle degeneration was greater in the CTX-injured model than in the glycerol-injured model at day 4 post injection. Muscle regeneration started at day 7 in both the CTX and glycerol models. However, the CTX-injured model showed a higher myotube density and larger myotube diameter than the glycerol-injured model at days 10 and 14 post injection. On other hand, adipocyte infiltration was detected in the glycerol-injured model. In contrast, no adipocytes could be detected in the CTX-injured model. Furthermore, ultrastructural analysis showed a significant difference in myofiber damage and regeneration between the two models. SEM of the IMCT showed a transient increase in endomysia...Continue Reading

References

Jan 1, 1990·Acta Neuropathologica·H KawaiM Iwasa
Jan 31, 2003·The Journal of Biological Chemistry·Joshua R Sanes
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·J B Harris
Dec 22, 2006·Ultrastructural Pathology·Panorea K PolitiGeorge Lyritis
Feb 1, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura PelosiAntonio Musarò
May 5, 2007·The Journal of Physiology·Gordon L WarrenPetia P Simeonova
Apr 2, 2008·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Li ZhaoXiao-tang Sun
Mar 23, 2010·The American Journal of Pathology·So-ichiro FukadaHiroshi Yamamoto
May 12, 2010·Biochemical and Biophysical Research Communications·Didier F PisaniClaude A Dechesne
Oct 27, 2010·Tissue Engineering. Part C, Methods·Allison R GilliesShyni Varghese
Jun 29, 2013·Bioarchitecture·Antonio S J LeeEdna C Hardeman
Aug 31, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Rongguo WangYunting Wang
Aug 27, 2014·Skeletal Muscle·Patrizia PessinaPura Muñoz-Cánoves

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Citations

Aug 16, 2016·FEBS Open Bio·Koichi OjimaTakanori Nishimura
Oct 7, 2016·Micron : the International Research and Review Journal for Microscopy·Mohamed A A MahdyYoshinao Z Hosaka
Jun 7, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Mohamed A A MahdyYoshinao Z Hosaka
Feb 6, 2017·Scientific Reports·Yaping NieYaosheng Chen
Oct 5, 2018·The Journal of Veterinary Medical Science·Mohamed A A MahdyYoshinao Z Hosaka
Jan 27, 2018·Nature Communications·Milica TosicRoland Schüle
Oct 5, 2019·Animal : an International Journal of Animal Bioscience·X LiM Du
May 3, 2020·The Journal of Physiology·Nicole K BiltzGretchen A Meyer
Jul 4, 2020·Connective Tissue Research·Yuji KanazawaYasufumi Shigeyoshi
Mar 16, 2017·Histochemistry and Cell Biology·Eustáquio Luiz Paiva-OliveiraJussara Lagrota-Candido
Jul 14, 2020·Frontiers in Molecular Neuroscience·Matteo RigonRüdiger Rudolf
Jul 31, 2019·Journal of Muscle Research and Cell Motility·Mohamed A A Mahdy
Nov 14, 2018·Cell and Tissue Research·Mohamed A A Mahdy
Sep 30, 2020·Journal of Cellular Physiology·Liyi Wang, Tizhong Shan
May 14, 2018·Cell and Tissue Research·Mohamed A A Mahdy
Nov 28, 2020·Journal of Cachexia, Sarcopenia and Muscle·Ziye XuTizhong Shan
Dec 8, 2020·BioMed Research International·Ya TanLi Zhu
Jun 5, 2021·Scientific Reports·Ariel WaismanDaniel Kopinke

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