Comparative study of nanosized cross-linked sodium-, linear sodium- and zinc-hyaluronate as potential ocular mucoadhesive drug delivery systems

International Journal of Pharmaceutics
Gabriella HorvátErzsébet Csányi

Abstract

Hyaluronic acid (HA) and its derivatives play important roles in many fields of therapy, such as arthritis treatment, plastic surgery, dermatology, otology, ophthalmology, etc. With a view to increase the beneficial properties of HA in ocular drug delivery, many types of chemical structural modifications have been performed. In the course of our research work, we characterized nanosized cross-linked - (CLNaHA), linear sodium hyaluronate (NaHA) and zinc-hyaluronate (ZnHA), as potential ocular drug delivery systems. The aim was to determine the influence of the structure on biocompatibility, mucoadhesion and drug release. The structure was characterized by means of rheology. The cytotoxicity of the samples was determined on rabbit corneal epithelial cells (RCE) by the MTT test. Mucoadhesion measurements were made by a rheological method in vitro and by tensile tests in vitro and ex vivo. The release of sodium diclofenac, a frequently used non-steroidal anti-inflammatory drug with low bioavailability, from the gels was determined with a vertical Franz diffusion cell. The results demonstrated that all three derivatives have adequate mucoadhesive properties and their rapid drug release profiles are beneficial in ocular therapy. Than...Continue Reading

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Citations

Nov 12, 2015·Drug Development and Industrial Pharmacy·Mária Budai-SzűcsErzsébet Csányi
Apr 11, 2017·Advanced Drug Delivery Reviews·Dileep R JanagamTao L Lowe
Jul 29, 2020·Diagnostics·Wolfgang G K Müller-Lierheim
Apr 30, 2021·Carbohydrate Polymers·Xiaodan ZhangQiang Zhu
Jul 12, 2021·International Journal of Pharmaceutics·Beatriz SilvaLídia Gonçalves

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