Comparative study of non-destructive methods to quantify thickness of tablet coatings

International Journal of Pharmaceutics
C CahyadiP W S Heng

Abstract

The Supercell coater is a newly introduced coater which utilizes air fluidization for tablet coating. The aim of this study was to define a suitable, fast and non-destructive method for the quantification of coat thickness for Supercell-coated tablets. Various coat thickness characterization methods were carried out on tablets coated at different process conditions. These include the use of optical microscopy, micrometer, X-ray fluorescence (XRF), Raman and near-infrared (NIR) spectroscopy. Coat thicknesses obtained from direct measurements were used to calibrate the spectral data from spectroscopic methods for model generation. The models were subsequently validated to evaluate their prediction capabilities, especially the ability to differentiate tablets coated at different conditions. XRF spectroscopy was viewed to be more suitable for the assessment of process yield and efficiency but both Raman and NIR spectroscopy were shown to be more appropriate methods for the rapid prediction and evaluation of coat thickness. However, only Raman spectroscopy was able to differentiate tablets coated under different conditions accurately. In conclusion, direct thickness measurements were more time-consuming but provided assured coat thi...Continue Reading

References

Feb 21, 2002·Pharmaceutical Development and Technology·Linda A Felton, W Lee Perry
Jun 1, 2005·Journal of Pharmaceutical and Biomedical Analysis·Saly Romero-TorresEdward R Grant
Dec 16, 2005·AAPS PharmSciTech·José D Pérez-RamosKenneth R Morris
Mar 1, 2006·Journal of Pharmaceutical and Biomedical Analysis·Saly Romero-TorresEdward R Grant
Jul 25, 2006·Journal of Pharmaceutical and Biomedical Analysis·John F KauffmanCharles R Cunningham
May 1, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·L HoJ A Zeitler
Nov 21, 2007·International Journal of Pharmaceutics·Ilgaz Akseli, Cetin Cetinkaya
Feb 29, 2008·Journal of Pharmaceutical Sciences·Cushla M McGoverinKeith C Gordon

❮ Previous
Next ❯

Citations

Feb 8, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Daniel MarklJohannes G Khinast
May 15, 2013·Drug Development and Industrial Pharmacy·Krisztina NikowitzPeter Kleinebudde
Feb 6, 2013·International Journal of Pharmaceutics·Klaus Knop, Peter Kleinebudde
Jan 2, 2016·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A K AgrawalA Sinha
Jul 27, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·D M KollerJ G Khinast
May 17, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Claire GendreJean Manuel Péan
Sep 8, 2015·International Journal of Pharmaceutics·Magdalena CzajkowskaPeter Kleinebudde
Apr 8, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Song PengXunliang Ding
Feb 15, 2012·International Journal of Pharmaceutics·Ju-Young KimEun-Seok Park
Sep 24, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C-V MöltgenG Reich
Jan 18, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dorián László GalataZsombor Kristóf Nagy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.