PMID: 7538210Jan 2, 1995Paper

Comparative study of normotensive and hypertensive nitric oxide synthase inhibitors on morphine withdrawal syndrome in rats

Neuroscience Letters
S L CappendijkM R Dzoljic

Abstract

The effects of the normotensive, mainly centrally active nitric oxide synthase (NOS) inhibitor 7-nitro indazole and the hypertensive drug NG-nitro-L-arginine, which blocks both the endothelial and the central NOS, have been examined on naloxone-precipitated withdrawal in morphine-dependent rats. Both drugs attenuated the same withdrawal signs (teeth-chattering, penile licking, diarrhoea, chewing, wet-dog shakes, grooming), while other signs remained unaffected (rearing, jumping, ptosis, rhinorrhoea, irritability on touch). These findings indicate that mainly central (but not endothelial) nitric oxide is involved in the expression of some opioid withdrawal symptoms.

References

May 27, 1992·European Journal of Pharmacology·H Prast, A Philippu
Sep 22, 1992·European Journal of Pharmacology·G LonartK M Johnson
Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluU Sayin
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Mar 30, 1990·Biochemical and Biophysical Research Communications·M HeckerJ R Vane
Dec 7, 1989·European Journal of Pharmacology·T B Van Wimersma GreidanusD H Versteeg
Dec 14, 1989·The New England Journal of Medicine·R J KraneI Saenz de Tejada
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y A KolesnikovG W Pasternak
Jun 1, 1993·Journal of Neuroscience Research·G LonartK M Johnson
Jun 1, 1993·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S L CappendijkM R Dzoljic

❮ Previous
Next ❯

Citations

Feb 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·J C LezaP Lorenzo
Nov 24, 1995·European Journal of Pharmacology·Y NodaT Nabeshima
Feb 6, 2004·European Journal of Pharmacology·Elaine A Del BelMarcela Bermúdez-Echeverry
Jan 1, 1996·Peptides·G A OlsonA J Kastin
Oct 7, 1998·Progress in Neurobiology·N Singewald, A Philippu
Dec 24, 2008·Anesthesiology·Noboru TodaHiroshi Toda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.