Comparative study of ophthalmological and serological manifestations and the therapeutic response of patients with isolated scleritis and scleritis associated with systemic diseases

Arquivos brasileiros de oftalmologia
Jacqueline Martins de SousaDenise de Freitas

Abstract

Scleritis is a rare, progressive and serious disease, the signs of which are inflammation and edema of episcleral and scleral tissues and is greatly associated with systemic rheumatoid diseases. To perform a prospective and comparative study between ophthalmologic manifestations, serologic findings and therapeutic response of patients with isolated scleritis and scleritis associated with systemic rheumatoid disease. Thirty-two outpatients with non-infectious scleritis were studied, from March 2006 to March 2008. The treatment was corticoid eye drops associated with anti-inflammatory agents, followed by systemic corticoids and immunosuppressive drugs if necessary, was considered successful after six months without scleritis recurrence. Fourteen of 32 patients had scleritis associated with systemic rheumatoid disease, of which nine had rheumatoid arthritis, two systemic lupus erythematosus, one Crohn's disease, one Behçet's disease and one gout. There were no difference in relation to involvement and ocular complications, there was predominance of nodular anterior scleritis and scleral thinning was the most frequent complication. The scleritis associated with systemic rheumatoid disease group had 64.3% of autoantibodies, versus 2...Continue Reading

Citations

Mar 25, 2016·Clinical & Experimental Ophthalmology·Jack AoRobert J Casson
May 29, 2020·Ocular Immunology and Inflammation·Amit PalkarParthopratim Dutta Majumder
Jun 7, 2020·Experimental Eye Research·D P C VergouwenM W J Schreurs
Sep 1, 2021·Ocular Immunology and Inflammation·D P C VergouwenM W J Schreurs

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