Comparative Study of Optical Coherence Tomography Angiography and Phase-Resolved Doppler Optical Coherence Tomography for Measurement of Retinal Blood Vessels Caliber

Translational Vision Science & Technology
Zohreh HosseinaeeKostadinka Bizheva

Abstract

To compare the accuracy of Doppler optical coherence tomography (DOCT) and OCT angiography (OCTA) for measuring retinal blood vessel caliber at different flow rates. A research-grade 1060-nm OCT system with 3.5-μm axial resolution in retinal tissue and 92,000 A scan/s image acquisition rate was used in this study. DOCT and OCTA measurements were acquired both from a flow phantom and in vivo from retinal blood vessels in six male Brown Norway rats. The total retinal blood flow (TRBF) was modified from baseline to 70% and 20% of baseline by reducing the ocular perfusion pressure (OPP). The retinal blood vessel caliber (RBVC) was measured from OCTA and DOCT images. The caliber measurements were conducted by two separate graders using a custom MATLAB-based image processing algorithm. The RBVC measured with OCTA and DOCT for normal blood flow rates were not significantly different (56.69 ± 12.17 and 57.17 ± 9.46 μm, P = 0.27, respectively). However, significant differences were detected when TRBF was reduced to 70% (55.69 ± 11.56 vs. 50.62 ± 8.85 μm, P < 0.01) and 20% (50.29 ± 9.29 vs. 44.88 ± 7.13 μm, P < 0.01) of baseline. Reduced TRBF resulted in inaccuracy of the RBVC measurements with DOCT in both the phantom and animal study. ...Continue Reading

References

Feb 1, 1995·Ophthalmology·C A PuliafitoJ G Fujimoto
Jan 1, 1995·Acta Ophthalmologica Scandinavica. Supplement·D C WuR Banwatt
Jun 23, 1998·Survey of Ophthalmology·A HarrisG A Cioffi
Jan 1, 2004·American Journal of Ophthalmology·Glenn J Jaffe, Joseph Caprioli
Feb 5, 2005·Ophthalmology·Paul MitchellRonald Klein
Apr 27, 2005·Investigative Ophthalmology & Visual Science·Gerhard GarhöferLeopold Schmetterer
Jan 28, 2009·Survey of Ophthalmology·Cong SunTien Y Wong
Aug 18, 2009·Acta Ophthalmologica·Gerhard GarhoferUNKNOWN Ocular Blood Flow Research Association
Apr 19, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Renata BlondalEinar Stefánsson
Sep 26, 2012·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·M Kamran IkramTien Y Wong
Jul 28, 2013·Journal of Biomedical Optics·Vivek J Srinivasan, Harsha Radhakrishnan
Aug 19, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yanling OuyangFlorian M Heussen
Jul 15, 2016·Investigative Ophthalmology & Visual Science·Klemens FondiLeopold Schmetterer
Nov 18, 2016·The British Journal of Ophthalmology·Khalil Ghasemi FalavarjaniSrinivas R Sadda
Jan 6, 2017·Journal of Biomedical Optics·Eric M MoultJames G Fujimoto
Feb 13, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lucia BenattiGiuseppe Querques
Mar 21, 2017·Investigative Ophthalmology & Visual Science·Bingyao TanKostadinka K Bizheva

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Software Mentioned

DOCT
MATLAB
OCTA

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