PMID: 7540856Jun 1, 1995Paper

Comparative study of peripheral blood progenitor cell collection in patients with multiple myeloma after single-dose cyclophosphamide combined with rhGM-CSF or rhG-CSF

British Journal of Haematology
H DemuynckM Boogaerts

Abstract

Patients suffering from high-risk multiple myeloma (MM) were randomized to receive single high-dose cyclophosphamide followed by either rhGM-CSF or rhG-CSF in order to harvest circulating peripheral blood progenitor cells. The safety of the procedure, the mobilization kinetics, the relative efficacy of rhGM-CSF and rhG-CSF to mobilize progenitor cells and their relative toxicity were studied. Special attention was paid to the antigenic profile of CD34+ progenitor cells. Group I patients (n = 11) were treated with cyclophosphamide 4 g/m2 i.v. followed by rhGM-CSF at 10 micrograms/kg/d by subcutaneous administration. Group II (n = 11) patients received rhG-CSF s.c. at 10 micrograms/kg/d after the same dose cyclophosphamide. Both mobilization regimens appeared to be equally effective. No significant differences in absolute numbers of circulating progenitors, determined by CD34 expression or in yields of MNC, CFU-GM, BFU-E and CD34 subsets were observed. rhGM-CSF administration resulted however in delayed haemopoietic recovery and an increased complication rate. We conclude that rhG-CSF may be preferred because of its markedly lower toxicity and lower in-hospital costs.

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H DemuynckN G Testa
Jul 2, 1992·The New England Journal of Medicine·G J Lieschke, A W Burgess
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B I LordT M Dexter
May 1, 1987·British Journal of Haematology·P J SelbyJ S Malpas
Apr 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D CunninghamP J Selby

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Citations

Jul 1, 1995·Annals of Hematology·H DemuynckM A Boogaerts
Jul 9, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·S TalhiM A Bekadja
Mar 7, 2014·Expert Opinion on Biological Therapy·Massimo MartinoFrancesco Lanza
Jan 21, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Dawn SheppardJason Tay
Nov 19, 2010·Expert Review of Hematology·Lloyd E Damon, Lauren E Damon
Jan 1, 1997·Vox Sanguinis·M J Watts, D C Linch

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