PMID: 6159919Dec 1, 1980Paper

Comparative study of proteinase inhibitors in human amniotic fluid and maternal serum

British Journal of Obstetrics and Gynaecology
A R Bhat, T N Pattabiraman

Abstract

Serum and amniotic fluid samples from five pregnant women were analyzed for different proteinase inhibitors by ion-exchange chromatography on DEAE-cellulose. Alpha-2 macroglobulin was found to be absent in amniotic fluid. Even though alpha-1 antichymotrypsin was identified in amniotic fluid, its concentration gradient between serum and amniotic fluid (20--60) was much higher than that of alpha-1 antitrypsin (8--20). Two forms of alpha-1 antitrypsin were identified in both the fluids. In pregnancy, the ratio of the two forms was altered in favour of the less anionic form compared to normal sera. The contribution of the heat stable proteinase inhibitor for total antitryptic activity in amniotic fluid was more than in serum. The observation that urine samples from immature infants had higher heat stable inhibitory activity than urine samples from normal infants suggests that the heat stable inhibitor in amniotic fluid may arise from fetal kidney.

References

Dec 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Ohlsson, U Akesson
Jul 1, 1978·The Biochemical Journal·P K Hall, R C Roberts
Mar 1, 1979·British Journal of Obstetrics and Gynaecology·A R BhatT N Pattabiraman
Mar 1, 1974·Arthritis and Rheumatism·M M Griffiths, R C Williams
Aug 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·R G Sutcliffe, D J Brock
Jan 1, 1965·Scandinavian Journal of Clinical and Laboratory Investigation·J O ALVSAKER

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Citations

Oct 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Maya RocheK Nalini
Aug 1, 1983·Biochemical Medicine·A R BhatT N Pattabiraman
Sep 1, 1989·The American Journal of Physiology·C F UyeharaJ R Claybaugh

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