Comparative study of retinal nerve fibre layer measurement by RTVue OCT and GDx VCC

The British Journal of Ophthalmology
Xiaozhen WangNingli Wang

Abstract

To evaluate the diagnostic performances and correlations of retinal nerve fibre layer (RNFL) thickness measured by RTVue OCT and GDx variable corneal compensation (VCC). The total and regional RNFL thickness were measured by RTVue OCT and GDx VCC in 62 normal eyes and 72 glaucomatous eyes of Chinese subjects. The RNFL thickness profiles of normal and glaucomatous eyes by RTVue OCT are plotted. Correlations of RNFL thickness measured by RTVue OCT and GDx VCC were assessed using the Pearson correlation. The discriminating abilities of the two techniques for detection of glaucoma were compared by the area under the receiver operating characteristic curves (AUC). RTVue OCT demonstrated double hump patterns in the RNFL profiles. In both normal and glaucomatous subjects, the peaks were located in the superotemporal (ST) and inferotemporal (IT) regions, and the troughs were located at the nasal (NU+NL) and temporal (TU+TL) regions. Despite poor agreement, a high correlation (r=0.821) was found between the mean RNFL measurements by RTVue OCT and GDx VCC. For RTVue OCT, the highest AUCs were mean RNFL (AUC=0.914) and inferior mean RNFL (AUC=0.909). The nerve fibre indicator (AUC=0.856) and inferior RNFL (AUC=0.852) achieved the highest ...Continue Reading

Citations

Mar 28, 2013·Investigative Ophthalmology & Visual Science·Renato LisboaFelipe A Medeiros
Mar 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jaromir T WasylukIwona Grabska-Liberek
Jun 1, 2013·Current Ophthalmology Reports·Daniel Meira-FreitasFelipe A Medeiros
Aug 27, 2013·American Journal of Ophthalmology·Renato LisboaFelipe A Medeiros
Aug 14, 2012·Ophthalmology·Renato LisboaFelipe A Medeiros
Mar 19, 2014·Ophthalmology·Atsuya MikiLinda M Zangwill
Jun 3, 2015·Journal of Glaucoma·Corinne MauriceEytan Z Blumenthal
Jun 13, 2015·The Open Ophthalmology Journal·Carolina P B GracitelliFelipe A Medeiros

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