PMID: 20118629Feb 2, 2010Paper

Comparative study of skin phototoxicity with three drugs by an in vivo mouse model

The Journal of Toxicological Sciences
Norihito MatsumotoSoonih Kim

Abstract

Photosafety evaluation is becoming important during the drug development process in pharmaceutical companies. Both in vitro and in vivo test systems have been developed for the evaluation of phototoxic potential of chemicals. In the present study, we conducted an in vivo phototoxicity test using BALB/c mice. The mice were treated with sparfloxacin, lomefloxacin, or a quinoline derivative orally followed by the irradiation of simulated sunlight, and resulting phototoxic reactions of the ears were assessed. Sparfloxacin and lomefloxacin, but not the quinoline derivative, are well known to cause photoirritation in humans. All three drugs exhibited positive reaction in the 3T3 neutral red uptake phototoxicity test (3T3 NRU PT). In the in vivo test, sparfloxacin and lomefloxacin exhibited positive skin reaction in mice, but the quinoline derivative did not. The results of in vivo phototoxicity test in the mice coincided with phototoxic potential of these drugs in humans. The exposure levels of sparfloxacin or lomefloxacin at the minimum effective dose that exhibited phototoxic reaction in the mice were comparable with those in humans treated with the recommended therapeutic dose.

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Citations

Feb 13, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jens SchümannDaniel Bauer
Jan 22, 2011·Veterinary Medicine International·Marcela Rebuelto, María Elena Loza
Feb 18, 2012·Cutaneous and Ocular Toxicology·Dena ElkeebHoward Maibach
Jul 21, 2011·Photochemistry and Photobiology·Guido de GuidiAlfio Catalfo
Nov 30, 2014·International Journal of Toxicology·Tamiko AdachiNaoya Masutomi
Dec 14, 2018·Toxicology Research·Xiaoqi LiLisha You
Oct 21, 2015·Toxicological Research

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