PMID: 6113483Jul 18, 1981Paper

Comparative study of subcutaneous, intramuscular, and intravenous administration of human insulin

Lancet
D R OwensJ M Burrin

Abstract

Human insulin derived from porcine insulin was given subcutaneously (s.c.), intramuscularly (i.m.), and intravenously (i.v.) to normal men. The dosage for all three routes was 0 . 075 IU/kg body weight. Diluting medium was administered by s.c. injection to obtain control values. Somatostatin (100 microgram/h) was given to inhibit pancreatic beta cell secretion. The plasma glucose responses to s.c. injection of this insulin into the anterior abdominal wall and to i.m. injection into the thigh were similar with respect to the extent, onset, and duration of effect. Plasma glucose fell from mean (+/- SE) pre-injection values of 4 . 3 +/- 0 . 15 and 4 . 4 +/- 0 . 27 mmol/l, to 3 . 06 +/- 0 . 25 and 2 . 98 +/- 0 . 16 mmol/l by 90 to 105 min for s.c. and i.m. studies, respectively, thereafter returning to mean basal level by 6 h after i.m. injection, but remaining about 0 . 5 mmol/l below basal level after s.c. injection. A much more sudden, but short-lived, hypoglycaemic response occurred after i.v. insulin, with plasma glucose failing from 4. 50 +/- 0 . 42 to 1 . 45 +/- 0 . 16 mmol/l by 25 min, returning to mean basal value after 3 1/2 h. The mean (+/- SE) peak insulin levels after s.c. and i.m. injection were 0 . 13 +/- 0 . 01 and ...Continue Reading

References

Nov 1, 1975·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D L HorwitzN Yanaihara
May 1, 1976·The Journal of Clinical Endocrinology and Metabolism·S M Guerra, A E Kitabchi
Dec 8, 1973·Lancet·K G AlbertiH Orskov
May 1, 1966·Journal of Clinical Pathology·F C Greenwood, J Landon
Nov 1, 1972·Diabetologia·T DeckertL Kerp
May 1, 1974·The Journal of Clinical Investigation·R S SherwinR Andres
Apr 18, 1981·British Medical Journal·D R OwensR G Newcombe
Dec 1, 1963·The Journal of Clinical Investigation·I A MIRSKYG PERISUTTI
Aug 6, 1960·Nature·D S NICOL, L F SMITH

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Citations

Jul 24, 1982·Lancet·G S FranklinM L Freedman
Jul 24, 1982·Lancet·K Egstrup, J Olsen
Nov 3, 1998·Clinical Endocrinology·G Dickstein
Jan 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·B GrønlundS Madsbad
Jan 1, 1993·Scandinavian Journal of Caring Sciences·L Engström, A Bergman
Jul 7, 1990·BMJ : British Medical Journal·J Thow, P Home
Oct 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·F H ZielC S Rosenberg
Nov 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·S M Furler, E W Kraegen
Aug 7, 2013·Molecular Pharmaceutics·Beata ChertokRobert Langer

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