PMID: 36295May 1, 1979

Comparative study of the action of tranquilizers on reinforcement systems

Farmakologiia i toksikologiia
I V Marusov

Abstract

In experiments on rats the benzodiazepine tranquilizers diazepam (0.5 -- 1 mg/kg), nitrazepam (0.5 -- 5 mg/kg), phenazepam (0.5 -- 5 mg/kg) and grandaxin (5 mg/kg) facilitated the reaction of self-stimulation (RS), with electrodes implanted in the area of the lateral hypothalamus and medial fascicle of the forebrain. Increased doses of the tranquilizers (up to 10 mg/kg) depressed RS, diminished the searching activity and muscle tone. The tranquilizer elroquil belonging to the phenothiazine series depressed RS in doses 15--35 mg/kg. Diazepam (0.2 and 1 mg/kg), nitrazepam (0.2 and 0.5 mg/kg) and phenazepam (0.2 and 1 mg/kg) reduced the latent period of the reaction of active avoidance (RA) during aversive electric stimulation of the medial lemnisk. In doses of 10 mg/kg the drugs inhibited RA. Elroquil and grandaxin raised the latent period of RA within the dosage range studied. The drug effects and efficacious dose ranges varied among the tranquilizers.

Related Concepts

Benzodiazepines
Brain
Dose-Response Relationship, Drug
Medicinal Plants Testing, Preclinical
Electric Stimulation Technique
Escape Reaction
Phenothiazines
Reaction Time
Psychological Reinforcement
Self Stimulation

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