PMID: 1233250Oct 10, 1975

Comparative study of the cardiac and peripheral vascular effects of strophantin K and lanatoside C in coronary heart disease

European Journal of Clinical Pharmacology
L MatosE Török


The effects of intravenous strophanthin K (0.125 and 0.25 MG) and lanatoside C (0.4, 0.8 and 1.6 mg) on systolic time intervals (STI) and impedance plethysmographic (IP)P values were studied in ten patients with compensated coronary heart disease. The heart rate decreased significantly during a two-hour study in the lying position after both glycosides and placebo; the systemic blood pressure remained unchanged. Electromechanical systole (QS2), left ventricular ejection time (LVET) and preejection period (PEP), corrected for heart rate (QS2I, LVETI, PEPI), showed no change after placebo. The glycosides caused no change in LVETI. QS2I was significantly shortened only after lanatoside C 1.6 mg. PEPI and ICT were significantly shortened by both doses of strophanthin K and lanatoside C; the effects were dose-related. Taking into consideration the effects of cardiac glycosides on STI, use of the index ICT/QS1, the quotient of isovolumic contraction time and electro-mechanical delay, is proposed, because it showed quite sensitively the increase in myocardial contractility after digitalis. The effect of strophanthin K could be detected 10 minutes, and that of lanatoside C 30-40 minutes, after injection. The amplitude of the IP curve a...Continue Reading


Apr 1, 1972·The Journal of Clinical Pharmacology and New Drugs·I L RubinH Gross
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Related Concepts

Coronary Heart Disease
Dose-Response Relationship, Drug
Pulse Rate
Heart Sounds
Myocardial Contraction
Plethysmography, Impedance

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