PMID: 7026259Jan 1, 1981Paper

Comparative study of the effect of azepexole and clonidine on blood pressure and pulse rate in normotensive subjects

European Journal of Clinical Pharmacology
L BenedikterD A Middleton

Abstract

In a double-blind cross-over study in 8 normotensive subjects azepexole was found to have a pharmacological profile identical to that of clonidine, although chemically there is no structural similarity between the two compounds. Compared to placebo, oral azepexole 5 and 10 mg and clonidine 0.15 mg produced a significant reduction in systolic and diastolic blood pressures both supine and standing (tilted). The reduction was greater in the standing than in the supine position. There was a significant slowing of the pulse rate only in the supine position, whereas the reflex increase in pulse rate on tilting was enhanced after both substances. The rise in diastolic blood pressure on tilting, however, was partically blocked by azepexole 10 mg. No dose dependent change in the pulse rate was observed. The maximum fall in blood pressure and pulse rate occurred between 1.5 and 4 h after ingestion of either substance, and had not returned to placebo level after 6 h, except for the supine systolic pressure after azepexole 5 mg. Dose-dependent sedation and dryness of the mouth were observed both after azepexole and clonidine. They followed approximately the same time-course as the haemodynamic changes. Although the hypotensive effect of az...Continue Reading

References

Aug 1, 1976·European Journal of Pharmacology·M LaubieM Drouillat
Jan 1, 1976·Clinical Pharmacology and Therapeutics·C T DolleryS Murray
May 1, 1970·European Journal of Pharmacology·H KluppH Teichmann
Sep 1, 1971·European Journal of Pharmacology·W Kobinger, A Walland
Aug 1, 1972·European Journal of Pharmacology·W Kobinger, A Walland
Aug 1, 1972·European Journal of Pharmacology·W Kobinger, A Walland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.