Comparative study of the effect of bilastine and cetirizine on cognitive functions at ground level and at an altitude of 4,000 m simulated in hypobaric chamber: a randomized, double-blind, placebo-controlled, cross-over study

Expert Opinion on Drug Safety
Ákos ReményiFrigyes Helfferich

Abstract

Antihistamines are easily accessible and cover the vast majority of the medical therapy of allergic rhinitis. However, their systemic administration may more frequently associate with their well-known side-effect, sedation, which is a serious problem in persons in safety-critical jobs such as aviation. We have a poor understanding whether a non-sedative antihistamine has an impact on vigilance when hypobaric hypoxia occurs during flight. In this randomized, placebo-controlled, double-blind, cross-over study the effect of 20 mg bilastine was compared to 10 mg cetirizine and to placebo (20 mg pyridoxine) in 33 individuals at ground level and at 4,000 m altitude simulated in hypobaric chamber. Levels of vigilance, ultrashort memory, combined distributive attention, monotony tolerance and peripheral blood oxygen saturation (SpO2) were assessed. Bilastine did not impair the tested abilities in comparison with the control groups either at ground level or hypobaric hypoxia. Administration of cetirizine increased the number of errors at ground level. At the simulated altitude, already impaired results were additionally demonstrated with regards to the distributive attention test. From the two examined antihistamines, bilastine should b...Continue Reading

References

Jan 1, 1997·American Journal of Rhinology·P J ValkM T van Berge Henegouwen
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I Hindmarch, Z Shamsi
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Boris A StuckJoachim T Maurer
Aug 23, 2008·Aviation, Space, and Environmental Medicine·Charles VacchianoGary Crawley
Nov 1, 2012·Methods : a Companion to Methods in Enzymology·M PazzagliS Gelmini
Nov 24, 2012·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Fusun Kalpaklioglu, Ayse Baccioglu
May 13, 2014·Allergy·E F P M VuurmanB Kremer
Nov 17, 2015·Expert Opinion on Drug Safety·Ignacio JáureguiLuis Labeaga
Aug 10, 2016·Aerospace Medicine and Human Performance·Pierre J L ValkLuis Labeaga
Nov 10, 2017·Clinical and Molecular Allergy : CMA·Marysia Tiongco RectoGiorgio Walter Canonica

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Citations

Oct 16, 2019·Current Medical Research and Opinion·Martin K ChurchZoltán Novák
Oct 30, 2019·Clinical and Translational Allergy·Nikolaos G Papadopoulos, Torsten Zuberbier
Jan 26, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Angelica TiotiuFulvio Braido

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