PMID: 754492Jan 1, 1978Paper

Comparative study of the effects of indomethacin and sodium salicylate on the renal circulation

Acta physiologica Academiae Scientiarum Hungaricae
J Bartha, C Hably

Abstract

Indomethacin and salicylates are considered to be specific inhibitors of prostaglandin (PG) synthesis. If their mechanism of actin is common then similar effects would be expected in organs capable of PG production. In the present investigation the effects on renal and intrarenal haemodynamics by indomethacin and Na-salicylate were studied and compared in anaesthetized (nembutal) dogs using SAPIRSTEIN's technique. Indomethacin (4 mg per kg) raised blood pressure while cardiac output remained unaffected. Sodium salicylate (200 mg per kg) also increased blood pressure, however, this was associated with increased cardiac output. Renal blood flow was depressed by indomethacin, whereas it was not influenced by Na-salicylate (RBFcontr. = 411 +/- 97; RBFindo. = 292 +/- 53, p less than 0.01; RBFNa-salic. = 468 +/- 110 ml per min per 100 g). Renal resistance was augmented after indomethacin and unaltered by Na-salicylate (Rcontr. = 1.96 +/- 0.43; Rindo. = 3.03 +/- 0.97, p less than 0.001; RNa-salic. = 1.91 +/- 0.49). Indomethacin provoked an intrarenal blood flow redistribution, while no such effect was seen by Na-salicylate. Salt and water excretion was markedly suppressed by indomethacin, whereas Na-salicylate exhibited diuretic and n...Continue Reading

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