Comparative study of the effects of osteoprotegerin and testosterone on bone quality in male orchidectomised rats.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
Marta Martín-FernándezConcepción de la Piedra

Abstract

Aim: The aim of this work is to compare the effects of osteoprotegerin (OPG) and testosterone on bone quality in a model of orchidectomised (ORX) rats.Methods: Three-month-old ORX or SHAM operated groups (n = 15 each group) were used. The SHAM and ORX groups received saline. There were two ORX groups, receiving OPG-Fc (10 mg/kg twice weekly) (ORX + OPG-Fc) or testosterone cypionate (1.7 mg/kg/weekly) for 8 weeks. After sacrifice, bone analysis by femoral and lumbar dual-energy X-ray absorptiometry and micro-computed tomography in femora were performed. Histological sections of vertebrae were dyed with hematoxylin-eosin or safranin. Serum osteocalcin (BGP), total alkaline phosphatase (ALP), and C-terminal telopeptide of type I collagen (CTX) were analyzed.Results: ORX resulted in femoral and vertebral bone loss and in microarchitectural deterioration. Treatment with OPG-Fc and testosterone recovered lumbar (L) and femoral (F) bone mineral densitometry bone mineral density (BMD) to SHAM levels. Femoral BMD was significantly higher after treatment with OPG-Fc than after testosterone treatment due to the presence of osteopetrotic changes in the metaphyseal region of long bones. Serum levels of ALP and CTX increased, while OPG level...Continue Reading

References

Jul 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R T TurnerK S Hannon
Aug 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R T TurnerN H Bell
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·H YasudaT Suda
Oct 15, 1998·The British Journal of Radiology·J Gala PaniaguaM Torralbo García
Sep 1, 1999·Clinical Endocrinology·R M Francis
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R G ErbenM Goldberg
Nov 30, 2000·Arthritis Research·S Roux, P Orcel
Jan 1, 1997·Computer Methods in Biomechanics and Biomedical Engineering·TOR Hildebrand, PETER Rüegsegger
Jul 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hirotaka KawanoShigeaki Kato
Jan 14, 2005·The New England Journal of Medicine·Vahakn B ShahinianJames S Goodwin
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Susan L GreenspanNeil M Resnick
Mar 7, 2006·Current Rheumatology Reports·Neveen A T Hamdy
Mar 27, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M S OminskyJ E Atkinson
Jul 20, 2007·Arthritis Research & Therapy·Brendan F Boyce, Lianping Xing
Jul 20, 2007·Arthritis Research & Therapy·Edward M Schwarz, Christopher T Ritchlin
Sep 5, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P TaxelJ A Lorenzo
Sep 11, 2008·American Journal of Physiology. Endocrinology and Metabolism·Joshua F YarrowStephen E Borst
Sep 30, 2008·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Lourdes BasurtoRosa Galván
Nov 18, 2008·Frontiers of Hormone Research·Stephen P Tuck, Roger M Francis
Mar 5, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael S OminskyPaul J Kostenuik
Oct 13, 2010·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Concepcion De La PiedraF Bauss
Dec 14, 2011·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W SiposP Pietschmann
Feb 7, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Olof RistoOla Wahlström
Mar 24, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Antonio AversaSilvia Migliaccio
Apr 16, 2013·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Pierre M G BoulouxUNKNOWN Study 43203 Investigators
Oct 19, 2013·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kazuyoshi ShigeharaMikio Namiki
Apr 14, 2015·Orthodontics & Craniofacial Research·D A SchneiderN E Hatch
Aug 1, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Naoki WadaHidehiro Kakizaki
Aug 22, 2015·European Journal of Orthodontics·Felipe J Fernández-GonzálezJose A Vega
Nov 4, 2016·Physiological Reviews·Maria AlmeidaStavros C Manolagas
Aug 10, 2017·Molecular and Cellular Endocrinology·Irene HunterIain J McEwan
Mar 7, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Sok Kuan WongKok-Yong Chin

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