Comparative study of the expression of cholinergic system components in the CNS of experimental autoimmune encephalomyelitis mice: Acute vs remitting phase

The European Journal of Neuroscience
Giovanni Di PintoGuadalupe Mengod

Abstract

Acetylcholine (ACh) is involved in the modulation of the inflammatory response. ACh levels are regulated by its synthesizing enzyme, choline acetyltransferase (ChAT), and by its hydrolyzing enzymes, mainly acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A more comprehensive understanding of the cholinergic system in experimental autoimmune encephalomyelitis (EAE) disease progression could pave the path for the development of therapies to ameliorate multiple sclerosis (MS). In this work, we analyzed possible alterations of the CNS cholinergic system in the neuroinflammation process by using a MOG-induced EAE mice model. MOG- and vehicle-treated animals were studied at acute and remitting phases. We examined neuropathology and analyzed mRNA expression of ChAT, AChE and the α7 subunit of the nicotinic acetylcholine receptor (α7nAChR), as well as AChE and BuChE enzyme activities, in brain and spinal cord sections during disease progression. The mRNA expression and enzyme activities of these cholinergic markers were up- or down-regulated in many cholinergic areas and other brain areas of EAE mice in the acute and remitting phases of the disease. BuChE was present in a higher proportion of astroglia and microglia/macro...Continue Reading

References

Nov 8, 1992·The Journal of Comparative Neurology·H TagoH Kimura
Oct 1, 1995·Clinical Immunology and Immunopathology·R H Swanborg
Jun 1, 1997·Brain Research. Molecular Brain Research·M TomiyamaG Mengod
Dec 5, 1998·Neuroscience Letters·L ZhangC Krieger
Dec 20, 2002·Nature·Kevin J Tracey
Mar 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M J KARNOVSKY, L ROOTS
Apr 2, 2004·Journal of Neurochemistry·R Douglas ShytleJun Tan
Oct 19, 2004·Neuropathology and Applied Neurobiology·L GiardinoL Calzà
Nov 1, 2006·Biochemical Society Transactions·V A Pavlov, K J Tracey
Jun 22, 2007·The European Journal of Neuroscience·Hyun Jung ParkByung Kwan Jin
Jan 29, 2008·CNS & Neurological Disorders Drug Targets·D CarnevaleL Minghetti
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mauricio Rosas-BallinaKevin J Tracey
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fu-Dong ShiRonald J Lukas
Jun 6, 2009·Journal of Internal Medicine·M Rosas-Ballina, K J Tracey
Nov 11, 2009·Brain Research·Soon-Tae LeeJae-Kyu Roh
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Athena M SoulikaDavid Pleasure
Sep 17, 2011·Science·Mauricio Rosas-BallinaKevin J Tracey
Jul 25, 2012·Annals of the New York Academy of Sciences·Koichiro KawashimaKazuhide Horiguchi
Dec 4, 2012·International Journal of Molecular Sciences·Marcella RealeAda Maria Tata
Jan 1, 2013·Journal of Chemical Neuroanatomy·Cristina SanabraGuadalupe Mengod
Jan 12, 2013·Neuroscience·G A ReidS Darvesh
Aug 14, 2013·Journal of Parkinson's Disease·Vanessa StuckenholzCarmen Noelker
Nov 22, 2014·Recent Patents on CNS Drug Discovery·Carlo Matera, Ada M Tata
Mar 5, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pramod K DashAnthony N Moore
Dec 6, 2016·International Journal of Molecular Sciences·Maria Di BariAda Maria Tata

❮ Previous
Next ❯

Citations

Sep 15, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·M W D ThorneS Darvesh
Jun 3, 2021·International Journal of Molecular Sciences·Roberta PiovesanaAda Maria Tata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.