PMID: 11604266Oct 18, 2001Paper

Comparative study of the leachability of di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate from haemodialysis tubing

International Journal of Pharmaceutics
K KambiaC Brunet

Abstract

The leachability of both Di(2-ethylhexyl) phthalate (DEHP) and Tri(2-ethylhexyl) trimellitate (TEHTM) or Trioctyl trimellitate (TOTM) from haemodialysis tubing was investigated in 20 patients with chronic renal failure undergoing maintenance haemodialysis. The blood tubing made of common polyvinyl chloride (PVC) plasticized with DEHP (group 1 patients) were replaced with tubing plasticized with TOTM-DEHP (group 2 patients). The patient blood obtained from the inlet and the outlet of the dialyzer was analyzed during a 4 h-dialysis session. Thus, the circulating concentrations of both DEHP and TOTM resulting from the release from dialyzer tubes were estimated using High-performance Liquid chromatograph (HPLC). With the common PVC-DEHP blood tubing, a DEHP quantity of 122.95+/-33.94 mg was extracted from tubing during a single dialysis session (ranging from 55 to 166.21 mg). During the same period, the total amounts of DEHP retained by the patients were 27.30+/-9.22 mg (ranging from 12.50 to 42.72 mg). As for blood tubing plasticized with TOTM-DEHP, 41.80+/-4.47 mg of DEHP and 75.11+/-25.72 mg of TOTM were extracted. During the same period, the amounts of DEHP and TOTM retained by the patients were 3.42+/-1.37 mg and 4.87+/-2.60 m...Continue Reading

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Citations

Dec 26, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yosuke TakahashiShigefumi Suehiro
Feb 12, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·E D S Van VlietR M Whyatt
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Jul 6, 2010·Néphrologie & thérapeutique·Philippe BrunetBernard Bruguerolle
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Oct 25, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yuji HaishimaShingo Niimi
Sep 28, 2015·The Science of the Total Environment·Thuy T BuiCynthia A de Wit
Jun 24, 2015·Nature Reviews. Nephrology·Anglina KatariaHoward Trachtman
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Feb 5, 2008·Asian Cardiovascular & Thoracic Annals·Yosuke TakahashiShigefumi Suehiro
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Feb 7, 2020·Advances in Colloid and Interface Science·Emil GustafssonAdrian R Rennie

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