Comparative study of the ophthalmological examinations in neurofibromatosis type 1. Proposal for a new screening algorithm

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
S CaenIngele Casteels

Abstract

Efforts are made to unify the protocol concerning the ophthalmological screening, monitoring and treatment of Optic Pathway Gliomas (OPGs) in children with neurofibromatosis type 1 (NF1). The aim of this study is to compare the most recent recommendations published in 2007 with the screening strategies in NF1 centres. The integration of these data resulted into a recommendation for an improved screening strategy. A literature search on PubMed between 1984 and 2013 was performed. A questionnaire on the ophthalmological screening in NF1 was sent to centres of expertise in the field of NF1. Literature and questionnaire data were analysed. Also, findings of a round table discussion on the ophthalmological screening of NF1 patients at the European Paediatric Ophthalmological Society (EPOS) meeting in 2013 were summarized. In most centres ophthalmological screening in NF1 patients is well organized, but is performed longer and at more regular intervals than is mentioned in the recommendations. Visual acuity testing, fundoscopy and pupillary reflexes are carried out unanimously. There is no uniformity of the ophthalmological screening in NF1 patients. The present recommendation advises to screen annually until the age of 8. Because OP...Continue Reading

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Jul 8, 2015·The Journal of Pediatrics·Beth A Pletcher, Caroline Hayes-Rosen
May 17, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Patrícia de Freitas DottoSolange Rios Salomão
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Oct 2, 2021·Journal of Pediatric Ophthalmology and Strabismus·Patrícia JoséFilipa Jorge Teixeira

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