PMID: 40816Nov 1, 1979

Comparative study of the sedative and tranquilizing effect of phenazepama and seduxen and their influence on human evoked brain potentials

Farmakologiia i toksikologiia
T M DarbinianO V Petrov


Phenazepam was compared to diazepam in a double-blind study made in 32 patients. The drugs were administered by month in doses of 0.0025 mg/kg and 0.005 mg/kg. respectively 1--2 days before surgery with the use of general anesthesia. Anxiety assessed by means of the brain evoked potential test and by a clinical test according to Gologorsky's scale reduced 2 hours following both phenazepam and diazepam administration. Phenazepam elicited a more pronounced and more lasting tranquilizing effect as compared to that of diazepam. Phenazepam was concluded to be a powerful anxiolytic and sedative agent recommended for premedication before surgical interventions.

Related Concepts

Reaction Time
Anti-Anxiety Effect
General Anesthesia [PE]
Evoked Potentials
Potentials, Event-Related
Clinical Trials

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