Comparative study of the therapeutic effects of glibenclamide or the fixed combination of glibenclamide-phenformin with those of gliclazide or chlorpropamide

Acta diabetologica latina
A E RaptisS A Raptis

Abstract

This study was designed to compare the therapeutic effects of glibenclamide or the fixed combination of glibenclamide-phenformin with those of gliclazide, chlorpropamide or biguanides in non-insulin-dependent diabetes. It is divided into two parts: a) in the retrospective study (473 subjects), glucose control of patients who were transferred from chlorpropamide, gliclazide, glibenclamide, glibenclamide + biguanide or metformin to the fixed combination glibenclamide-phenformin in the same tablet (2.5 mg and 25 mg, respectively) was monitored. A statistically significant decrease of blood glucose and glycosylated hemoglobin values was found under the combination of glibenclamide-phenformin contained in the same tablet in contrast to the values obtained with the treatment with glibenclamide, gliclazide, chlorpropamide, combination of glibenclamide and biguanides, metformin, and insulin. b) In the prospective study (57 subjects), the patients were transferred from chlorpropamide or gliclazide to glibenclamide for 3 months and then reallocated to the previous treatment for 3 additional months. It was found that under glibenclamide, glucose control was significantly better than under chlorpropamide or gliclazide. In conclusion, glibe...Continue Reading

References

Jan 1, 1978·Contributions to Nephrology·A HeidlandD Deppermann
Mar 1, 1987·Diabetes Research and Clinical Practice·G JerumsT J Martin
Aug 1, 1968·Diabetes·A CzyzykZ Szczepanik
Mar 26, 1968·Annals of the New York Academy of Sciences·R A Altschuld, F A Kruger
Jul 1, 1969·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R GobernaE F Pfeiffer
Sep 1, 1972·Clinical Pharmacology and Therapeutics·F J Ayd, P Calabresi
Feb 18, 1971·The New England Journal of Medicine·L A TrivelliH T Lai
Apr 18, 1969·Deutsche medizinische Wochenschrift·H Mehnert, E Karg
Jan 14, 1967·Nature·F MeyerH Clauser
Sep 1, 1980·The Journal of Clinical Investigation·M J Prince, J M Olefsky
Sep 3, 1981·The New England Journal of Medicine·A HolleH W Rüdiger
Oct 7, 1955·Deutsche medizinische Wochenschrift·H FRANKE, J FUCHS

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Citations

Dec 10, 1999·Diabetes/metabolism Research and Reviews·C S Bartsocas

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