PMID: 6414252Jan 1, 1983Paper

Comparative study of tocainide and lidocaine in patients admitted for suspected acute myocardial infarction

Acta Medica Scandinavica
N RehnqvistA Sjögren

Abstract

The antiarrhythmic effects of tocainide, administered as a bolus injection of 750 mg followed by oral therapy, and conventional lidocaine therapy were evaluated in 40 patients admitted for suspected acute myocardial infarction (AMI) and showing high-grade premature ventricular complexes (PVCs). The mean hourly PVC rate before therapy was 928 and its reduction was equally significant in the tocainide group, 73%, and in the lidocaine group, 68%. The number of 5-minute periods with multiform, paired and R/T PVCs or ventricular tachycardia was also significantly reduced, by 78% in the tocainide group and by 71% in the lidocaine group. Ten patients in the tocainide group reported moderate side-effects, compared to 13 in the lidocaine group, where the infusion had to be discontinued in 5 patients and the rate had to be reduced in 4. Tocainide, an amine analogue of lidocaine, is considered just as effective as lidocaine in patients with high-grade PVCs and suspected AMI.

References

Jan 1, 1979·Journal of Cardiovascular Pharmacology·R W CampbellD G Julian
Nov 1, 1978·Medicine·J W Noneman, J F Rogers
Apr 1, 1978·Circulation·J L AndersonD C Harrison
Apr 1, 1976·Clinical Pharmacology and Therapeutics·D G McDevittJ A Oates
Jun 1, 1973·Circulation·B D KosowskyR F Ritchie
Dec 20, 1980·Lancet·D A ChamberlainR G Shanks

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Citations

Aug 22, 2015·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalShrikant Bangdiwala

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