Comparative study of tranexamic acid and norethisterone in the treatment of ovulatory menorrhagia

British Journal of Obstetrics and Gynaecology
J T PrestonS K Smith

Abstract

To compare the efficacy and safety of tranexamic acid and norethisterone in the treatment of ovulatory menorrhagia. A randomised, double-blind, placebo controlled study. University Department of Obstetrics and Gynaecology, Addenbrooke's Hospital, Cambridge. One hundred and three women complaining of heavy periods with a regular cycle recruited directly from general practitioners within the hospital catchment area and from consultants' gynaecology clinics. There were forty-six women on placebo with confirmed ovulatory menorrhagia, defined as menstrual blood loss greater than 80 ml/cycle and mid-luteal serum progesterone concentration greater than 9 nmol/l). Twenty-one received norethisterone (5 mg twice a day on days 19 and 26) and 25 received tranexamic acid (1 g four times daily on days 1 to 4) for two cycles. Menstrual blood loss was measured using the alkaline haematin method. Haematological assessments were made both at the beginning and at the end of the study, questionnaires were given to assess subjective endpoints, and patients were asked to report any adverse events during all cycles. Tranexamic acid reduced mean menstrual blood loss by 45%, from 175 ml to 97 ml (95% CI for the difference in menstrual blood loss 52 to ...Continue Reading

Associated Clinical Trials

Sep 22, 2016·Magdy Milad, MD

References

Jul 3, 1976·Lancet·E Rydin, P O Lundberg
Jul 1, 1991·British Journal of Obstetrics and Gynaecology·G ChamberlainL Eve
Nov 1, 1990·The Australian & New Zealand Journal of Obstetrics & Gynaecology·I S Fraser
Jun 1, 1989·Obstetrical & Gynecological Survey·M A Van EijkerenA A Haspels
Jun 1, 1989·Baillière's Clinical Obstetrics and Gynaecology·I S Fraser
Jul 1, 1989·British Journal of Obstetrics and Gynaecology·C J DockerayJ Bonnar
Aug 1, 1985·American Journal of Obstetrics and Gynecology·P A WingoH B Peterson
Oct 24, 1970·British Medical Journal·S T CallenderE Cope
Dec 1, 1980·British Journal of Obstetrics and Gynaecology·T H ChimbiraA C Turnbull
Aug 1, 1982·British Journal of Obstetrics and Gynaecology·G AgnelliG G Nenci
Apr 9, 1960·British Medical Journal·P M BISHOP, J C CABRAL DE ALMEIDA
Jan 1, 1964·Scandinavian Journal of Clinical and Laboratory Investigation·L HALLBERG, L NILSSON

❮ Previous
Next ❯

Citations

Apr 19, 2013·Archives of Gynecology and Obstetrics·Azita GoshtasebiSamira Behboudi Gandevani
Jun 30, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·Nassera S Banu, Isaac T Manyonda
Mar 24, 2004·Maturitas·Marlies Y BongersHans A M Brölmann
Jan 15, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·U H Winkler
Sep 11, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T Justin ClarkJanesh K Gupta
Feb 24, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·A StewartW Phillips
Jan 1, 1995·International Journal of Technology Assessment in Health Care·A CoulterM C Rees
Sep 8, 2001·Current Opinion in Obstetrics & Gynecology·M G Munro
Jan 19, 1999·Obstetrical & Gynecological Survey·S A StabinskyJ L Breen
Jun 25, 2005·Current Opinion in Obstetrics & Gynecology·Julia Osei, Hilary Critchley
Apr 5, 2005·Clinical Obstetrics and Gynecology·Rameet H Singh, Paul Blumenthal
Jun 15, 2006·American Journal of Therapeutics·Ricardo P GarayPatrick Hannaert
Mar 21, 2007·Obstetrical & Gynecological Survey·Anita L Nelson, Stephanie B Teal
May 22, 2007·Clinical Obstetrics and Gynecology·Malcolm G Munro
Sep 10, 1999·BMJ : British Medical Journal·C Kelleher, P Braude
Nov 24, 1999·BMJ : British Medical Journal·A Prentice
Sep 8, 2012·International Journal of Women's Health·Henri Leminen, Ritva Hurskainen
Jun 27, 2003·Drugs·Keri Wellington, Antona J Wagstaff
Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·O Graesslin, E Derniaux
Jul 15, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·H RomanL Marpeau
Jul 16, 2014·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Oded GiladGil Klinger
Sep 24, 2011·Journal of Women's Health·Måns Edlund
Mar 21, 2012·Journal of Women's Health·Ken MuseTammie L Adomako
Oct 31, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A KriplaniS Diwakar
Jan 7, 2015·Thrombosis Research·Lilian TengbornErik Berntorp
Aug 7, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H MarretUNKNOWN CNGOF Collège National des Gynécologues et Obstétriciens Français
Jun 17, 2000·Obstetrics and Gynecology Clinics of North America·M G Munro
Aug 10, 2015·American Journal of Obstetrics and Gynecology·Linda D Bradley, Ndeye-Aicha Gueye
Jan 11, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Becky Naoulou, Ming C Tsai
Feb 14, 2006·Contraception·Vorapong PhupongSurasak Taneepanichskul
Jul 20, 2011·Expert Opinion on Pharmacotherapy·Mary Ann Lumsden, Lilantha Wedisinghe
Nov 7, 2013·The Journal of Oral Implantology·Dennis Flanagan
Jul 23, 2011·American Journal of Obstetrics and Gynecology·Ellen W FreemanTammie L Adomako
Aug 24, 2002·American Journal of Obstetrics and Gynecology·Georgina L JonesCrispin Jenkinson
Feb 24, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·C Kremer, S Duffy
Nov 1, 1996·The Australian & New Zealand Journal of Obstetrics & Gynaecology·C M Farquhar, R M Kimble
Jul 20, 2012·The Annals of Pharmacotherapy·Sandra L Hrometz
Dec 5, 2017·Anesthesiology·Jerrold H LevyNigel S Key
Apr 16, 2018·The Cochrane Database of Systematic Reviews·Alison C Bryant-SmithMartha Hickey
May 3, 2013·Obstetrics and Gynecology·Kristen A MattesonUNKNOWN Society of Gynecologic Surgeons Systematic Review Group
Jul 20, 2007·The Cochrane Database of Systematic Reviews·H BeaumontA Lethaby
Jun 28, 2005·American Journal of Hematology·Jody L Kujovich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.