Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes

Materials Science & Engineering. C, Materials for Biological Applications
Maira Gaspar TosatoLelia Dicelio

Abstract

Trans-resveratrol (3, 5, 4' trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like avoiding gastrointestinal problems and first pass metabolism. However, its therapeutic potential is limited by its low solubility and low stability in water and the reduced permeability of stratum corneum. To overcome these inconveniences the encapsulation of this compound in a drug delivery system is proposed here. In order to find the best carrier for transdermal application of RSV various liposomal nanoparticulate carriers like conventional liposomes (L-RSV), deformable liposomes (LD-RSV), ultradeformable liposomes (LUD-RSV) and ethosomes (Etho-RSV) were assayed. Transmission electron microscopic (TEM) and dynamic light scattering (DLS) studies were performed to analyze the surface morphology of these carriers. Structural characterization for these formulations was performed by confocal Raman spectroscopy. The spectroscopic results were analysed in conjunction with calorimetric data to identify the conformational changes and stabil...Continue Reading

Citations

Jul 30, 2019·Critical Reviews in Analytical Chemistry·Bruno Vincenzo Fiod RiccioMarlus Chorilli
Nov 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ying-Chen ChengHui-Min David Wang
Jun 3, 2021·Advanced Healthcare Materials·Yi WangXuanhong Cheng

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