Comparative study of trichloroacetic acid versus glycolic acid chemical peels in the treatment of melasma

Indian Journal of Dermatology, Venereology and Leprology
Rashmi Kumari, Devinder Mohan Thappa

Abstract

Melasma is a common cause of facial hyperpigmentation with significant cosmetic deformity. Many modalities of treatment are available, but none is satisfactory. This study was designed to compare the therapeutic response of melasma in Indian women to glycolic acid (GA 20-35%) versus trichloroacetic acid (TCA 10-20%) for chemical peeling. Forty nonpregnant female patients with a minimum melasma area and severity index (MASI) of 10 were recruited in the study. After a detailed history and clinical examination under natural light, MASI was calculated and color photographs were taken of all the patients. The patients were advised to carry out a prepeel program of daily application of 12% GA cream or 0.1% tretinoin at night for 2 weeks. They were then treated with graded concentrations of 20-35% GA facial peel every 15 days in GA group and 10-20% TCA in the second group. Objective response to treatment evaluated by reduction in MASI scoring after 12 weeks was by 79% reduction (from 26.6 to 5.6) in GA group and by 73% reduction in TCA group (from 29.1 to 8.2) but this difference was not significant. Patients with epidermal-type melasma showed a better response to treatment than those with mixed-type melasma (P<0.05). Subjective respo...Continue Reading

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Citations

Feb 5, 2013·Journal of Cutaneous and Aesthetic Surgery·Rashmi SarkarVijay K Garg
Oct 2, 2014·Dermatology and Therapy·Krupa ShankarSalman Abdulrehman Motlekar
May 30, 2012·Seminars in Cutaneous Medicine and Surgery·Sailesh KondaRebat M Halder
Mar 27, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Gabriella FabbrociniGiuseppe Monfrecola
Oct 23, 2013·The British Journal of Dermatology·A SalamH Galadari
Mar 11, 2015·The Australasian Journal of Dermatology·Michelle Rodrigues, Amit G Pandya
Dec 22, 2017·Indian Journal of Dermatology·Rashmi SarkarSurabhi Sinha
Aug 24, 2017·Journal of Cosmetic Dermatology·Ebtisam Elghblawi
Feb 9, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Azza M Abdel-MeguidSahar A Ismail
Aug 30, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Shimona GargAnand Kumar
Jul 30, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Marlena KubiakHelena Rotsztejn
Sep 1, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Philip R Cohen
Mar 12, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Vasanop VachiramonPunyaphat Sirithanabadeekul
Nov 17, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Ahmad NofalRania Alakad
Feb 25, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ensaf M Abdel-MajidAmira A Abdel Motaleb

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