Comparative study of two antimicrobial dressings in infected leg ulcers: a pilot study

Journal of Wound Care
G MostiN Angelotti

Abstract

The aim of the study was to compare the efficacy of a microorganism-binding (MB) dressing with a silver-containing hydrofiber (SCH) dressing in controlling the bacterial loads of heavily colonised or locally infected chronic venous leg ulcers, before surgical management with homologous skin grafts. A randomised comparative single centre study recruited patients presenting with hard-to-heal critically colonised or locally infected leg ulcers, who could be treated with skin grafting. Inclusion criteria included; ulcers of vascular aetiology, over 18 years old, a wound duration ≥6 months and ankle brachial index (ABPI) >0.6. Patients were randomly assigned to treatment with SCH dressings (Aquacel Ag) or MB dressing (Cutimed Sorbact). Dressings were changed daily over a four-day observation period, after which they were taken for a skin grafting procedure. Swab samples from ulcer beds were taken in order to quantify the bacterial load at inclusion (D0) and at the end of the observation period day 4 (D4). No antibiotics were administered before or during the evaluation period. Both groups (n=20 SCH, n=20 MB) were similar in gender, age, pathophysiology (both had 15 patients with venous leg ulcers and 5 with arterial leg ulcers), ulc...Continue Reading

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Citations

Jun 17, 2015·Journal of Wound Care·Keith Cutting, James McGuire
Jun 16, 2018·The Cochrane Database of Systematic Reviews·Gill NormanJo C Dumville
Aug 7, 2018·International Wound Journal·Wibke L EngelbergStefanie Reich-Schupke
Dec 4, 2020·World Journal of Clinical Cases·Shi-Yan RenRong-Ding Gao
Jun 11, 2021·Seminars in Interventional Radiology·Sarah E Schroeppel DeBackerJeffrey L Weinstein
Jun 26, 2021·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Maxim E ShaydakovUNKNOWN American Venous Forum Research Committee

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biopsy
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