PMID: 3139613Jul 1, 1988

Comparative study on antagonistic effects of low pH and cation supplementation on in-vitro activity of quinolones and aminoglycosides against Pseudomonas aeruginosa

The Journal of Antimicrobial Chemotherapy
J Blaser, R Lüthy

Abstract

The antagonistic effects of physiological levels of Ca++ and Mg++ on the in-vitro activity of aminoglycosides and quinolones against Pseudomonas aeruginosa were studied at both pH 7.4 and 5.5. Adding Mg++ and Ca++ (100 mg/l) to commercial media deficient of these cations increased the MICs and MBCs of ciprofloxacin and enoxacin four-fold (2 P less than 0.01), which was significantly less than the 16-fold increase found for gentamicin and netilmicin (2 P less than 0.01). However, the activity of both aminoglycosides and quinolones was similarly affected by reducing the pH to 5.5 (giving eight-fold increases in MICs) or by the combination of both low pH plus cation supplementation (giving 16-fold increases in MICs). These data raise the question whether antagonizing factors should be considered not only for aminoglycosides, but also for quinolones during routine susceptibility tests on P. aeruginosa.

Citations

Jun 22, 1990·Pharmaceutisch Weekblad. Scientific Edition·R Janknegt
Jul 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C KönigJ Blaser
Feb 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·S A Brown
Mar 1, 1991·Antimicrobial Agents and Chemotherapy·M Michea-HamzehpourJ C Pechere
Mar 1, 1995·Antimicrobial Agents and Chemotherapy·C PelletierP Bourlioux
Apr 1, 1995·Journal of Chemotherapy·M H TeixeiraF Teixeira
Nov 1, 1991·DICP : the Annals of Pharmacotherapy·B M Lomaestro, G R Bailie

Related Concepts

Aminoglycosides
Microbicides
Antibiotics
Calcium
Hydrogen-Ion Concentration
Magnesium
Pseudomonas aeruginosa
4-Quinolones

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