Comparative study on the 3H-thymidine index of dorsal epidermis, buccal mucosa, and seminal vesicles in senile male rats

Archives of Dermatological Research
O P Hornstein, H Schell

Abstract

To supplement previous investigations on endogenous fluctuations of DNA synthesis in male rat dorsal epidermis, buccal mucosa and seminal vesicle epithelium from birth to sexual maturity, the labelling indices (L.I.) of these tissues in senile male rats from the same breed, studied under analogous experimental conditions, were evaluated as well as compared to the data obtained from rats in puberal and early mature age. In the dorsal epidermis and buccal mucosa of the old animals the medium L.I. were found to be at about the same level as those measured after puberty. In the aged seminal vesicle epithelium the medium L.I. was found to be decreased. The maintenance of epidermal and buccal DNA synthesis in senile rats as well as the results of previous studies with male rats subjected to castration or long-term administration of cyproteron acetate furnish evidence that a deficiency of testosteron does not diminish the rate of DNA synthesis in epidermis and buccal mucosa. However, from the decreased L.I. in seminal vesicle epithelium a reduced blood level or stimulating capacity, respectively, of testosteron in senile rats can be concluded. Furthermore, withdrawal of testosteron by orchidectomy or administration of cyproteron aceta...Continue Reading

References

Jun 11, 1974·Archiv Für Dermatologische Forschung·H SchellO P Hornstein
Sep 1, 1973·The Journal of Investigative Dermatology·P FrostE C Gomez
Jun 1, 1965·American Journal of Physical Anthropology·H MachidaL Giacometti
Jan 1, 1967·Dermatologica·A Pietrzykowska, J Konecki
Jul 1, 1965·Archives of Dermatology·F D BertalanffyM O Abbott

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Citations

Jun 25, 1979·Archives of Dermatological Research·R Maidhof, O P Hornstein
Sep 2, 2008·Archives of Dermatological Research·Fukumi FurukawaYoshiki Miyachi
May 12, 2011·Age·Rasha Abu EidTakashi Saku
Jun 16, 2016·AAPS PharmSciTech·Soledad Montero-PadillaJavier O Morales

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