Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A

Fitoterapia
Mei XueZhixing Zhou

Abstract

Tripterygium Glycosides (TG) is effective in the treatment of patients with a variety of inflammatory and autoimmune diseases, especially rheumatoid arthritis (RA) in clinical. Wilforlide A (T(1)) serves as a quality control standard of TG that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. The pharmacologic actions of T(1) remain to be unidentified. In this paper, we studied the anti-inflammatory and immune suppressive effect of T(1), and compared it with Triptolide (TP), which believed to be the major active component of TG. Carrageenan-induced rat pedal swelling, tampon-induced rat granulation, and mice ear inhibition rate of swelling trail results show that high-dose T(1) has obvious anti-inflammatory effect. Colorimetric detection contents of hemolysin, carbon elimination from plasma of mice, mice delayed hypersensitivity immune, and organ index were measured. The results show that T(1) has no significant immune suppressive activity, and there has a significant difference with TP and TG. Therefore, we think the content of TP also should be controlled as a supplement standard in order to ensure safe and effective medication.

References

Jul 26, 2006·Journal of Asian Natural Products Research·J-H YangL Li
Jan 26, 2007·Phytochemistry·Anita M BrinkerIlya Raskin

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Citations

Nov 19, 2011·Biochemical and Biophysical Research Communications·Lixin SunLuyong Zhang
Sep 7, 2013·Toxicology Letters·Lixin SunLuyong Zhang
Jun 16, 2015·Chinese Journal of Natural Medicines·Hai-Nan ShenTao Wang
Aug 14, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mei XueShu-yu Yang
Jun 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kunbei LaiChenjin Jin

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