PMID: 11326668May 1, 2001Paper

Comparative study on the clinical use of protein S-100B and MIA (melanoma inhibitory activity) in melanoma patients

Anticancer Research
C SchmitzA Hauschild

Abstract

The guidelines for the care of melanoma patients have not recommended the routine use of tumor markers up till now. In comparison to the blood parameters, two serum proteins have demonstrated their usefulness in the follow-up of melanoma patients: protein S-100B, a member of the S100 protein family, and "Melanoma-inhibitory activity" (MIA), a recently described 11 kd soluble protein. We analysed the serum levels of S-100B and MIA in non-melanoma control patients and in melanoma patients in different stages of disease (stage I-IV) to report on the sensitivity and specificity of both tumor markers. The serum concentration of S-100B was evaluated by a luminoimmunometric assay (LIA) in 670 blood samples of 87 melanoma patients and, as controls, in 169 blood samples of patients with different skin diseases apart from melanoma. MIA serum levels were measured by an enzyme-linked immunoassay (ELISA) in 791 serial blood samples of 87 melanoma patients and in 158 blood samples of control patients. A cut-off of 0.12 microgram/l (S-100B) and 6.5 micrograms/l (MIA) served as upper normal values in the melanoma group as recommended by the producing industrial companies. In the control patient group, we additionally used the cut-off value of ...Continue Reading

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