PMID: 7028134Oct 12, 1981Paper

Comparative study on the effects of a hypoglycemic 2-substituted-2-imidazoline derivative (DG-5128) and tolbutamide on insulin secretion from and insulin synthesis in the isolated rat pancreatic islets

Biochimica Et Biophysica Acta
K KamedaY Abiko

Abstract

2[2-(4,5-Dihydro-1H-imidazol-2-yl)-1-phenylethyl]pyridine dihydrochloride sesquihydrate (DG-5128) was found to stimulate the glucose-primed insulin secretion from the isolated rat pancreatic islets throughout the incubation period, unlike tolbutamide which stimulated it only in the initial phase of incubation. The effect of DG-5128 was more pronounced at a higher glucose concentration (5 mg/ml). In the islet perifusion study, DG-5128 was also found to stimulate the glucose-induced insulin secretion in both the first and the second phases of the reaction, in contrast to tolbutamide which stimulated only the first phase of insulin secretion from the perifused islets. DG-5128 gave no significant effect on the glucose-stimulated increase in incorporation of [3H]leucine into the proinsulin and insulin fractions, while tolbutamide significantly inhibited the incorporation especially at a low glucose concentration (1 mg/ml). These and the previous findings indicate that DG-5128 is a new class of hypoglycemic agent with a unique mode of action different from the known hypoglycemics ever reported.

References

Oct 1, 1976·Diabetologia·H LaubeE F Pfeiffer
Sep 1, 1968·Endocrinology·D L CurryG M Grodsky
Jul 1, 1970·The Journal of Clinical Investigation·T TaneseL Recant
Jun 1, 1970·Biochimica Et Biophysica Acta·G E Morris, A Korner

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Citations

Nov 27, 1984·European Journal of Pharmacology·K YamanakaI Muramatsu
Jun 1, 1989·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M FujimakiH Hakusui
Mar 1, 1987·British Journal of Pharmacology·M G Garrino, J C Henquin
Feb 1, 1993·Diabetes Research and Clinical Practice·K OhnedaF Koizumi
Jan 1, 1988·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Y YoshieT Nakazawa
Jan 1, 1990·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·T NakazawaY Yoshie
Jan 1, 1995·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·H SakaiT Nakazawa
Jan 1, 1995·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·H SakaiT Nakazawa
Jun 1, 1985·Metabolism: Clinical and Experimental·O E OwenG Boden
Mar 1, 1985·Japanese Journal of Pharmacology·K YamanakaI Muramatsu

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