Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam

British Journal of Clinical Pharmacology
E GoetzkeI B Welbers


Efficacy of and tolerance to 0.25 mg brotizolam and 0.25 mg triazolam were compared in hospitalised patients (aged 20 to 69 years) with sleep difficulties. Over 6 days there were no differences in efficacy and tolerance. The physicians reported the effectiveness of the drugs as good-to-satisfactory in 88.6% with brotizolam and 92.0% with triazolam. The patients reported with both drugs reduced time to fall asleep, less awakenings, increased duration of sleep and improved condition on awakening.


Jan 1, 1981·Clinical Pharmacology and Therapeutics·F S EbertsR W Vliek
Jan 1, 1983·British Journal of Clinical Pharmacology·F J KuhnK Stockhaus
Jan 1, 1983·British Journal of Clinical Pharmacology·R JochemsenD D Breimer
Jan 1, 1983·British Journal of Clinical Pharmacology·E GoetzkeI B Welbers
Jan 1, 1983·British Journal of Clinical Pharmacology·F AhmadJ Köster
Jan 1, 1983·British Journal of Clinical Pharmacology·W D Bechtel
Mar 1, 1980·Clinical Pharmacology and Therapeutics·D J GreenblattR I Shader


Sep 16, 1989·Lancet·R F Drucker, N MacLeod
Jan 6, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S Yamawaki
Nov 26, 2013·The Cochrane Database of Systematic Reviews·Allison Hirst, Richard Sloan
Feb 7, 2008·The Cochrane Database of Systematic Reviews·D Bereczki, I Fekete

Related Concepts

Clinical Trials
Double-Blind Method
Drug Tolerance
Sedative Effect
Subwakefullness Syndrome
Anti-Anxiety Effect

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.