Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam

British Journal of Clinical Pharmacology
E GoetzkeI B Welbers

Abstract

Efficacy of and tolerance to 0.25 mg brotizolam and 0.25 mg triazolam were compared in hospitalised patients (aged 20 to 69 years) with sleep difficulties. Over 6 days there were no differences in efficacy and tolerance. The physicians reported the effectiveness of the drugs as good-to-satisfactory in 88.6% with brotizolam and 92.0% with triazolam. The patients reported with both drugs reduced time to fall asleep, less awakenings, increased duration of sleep and improved condition on awakening.

References

Jan 1, 1981·Clinical Pharmacology and Therapeutics·F S EbertsR W Vliek
Jan 1, 1983·British Journal of Clinical Pharmacology·F J KuhnK Stockhaus
Jan 1, 1983·British Journal of Clinical Pharmacology·R JochemsenD D Breimer
Jan 1, 1983·British Journal of Clinical Pharmacology·E GoetzkeI B Welbers
Jan 1, 1983·British Journal of Clinical Pharmacology·F AhmadJ Köster
Jan 1, 1983·British Journal of Clinical Pharmacology·W D Bechtel
Mar 1, 1980·Clinical Pharmacology and Therapeutics·D J GreenblattR I Shader

Citations

Sep 16, 1989·Lancet·R F Drucker, N MacLeod
Jan 6, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S Yamawaki
Nov 26, 2013·The Cochrane Database of Systematic Reviews·Allison Hirst, Richard Sloan
Feb 7, 2008·The Cochrane Database of Systematic Reviews·D Bereczki, I Fekete

Related Concepts

Lindormin
Azepines
Clinical Trials
Double-Blind Method
Drug Tolerance
Hospitalization
Sedative Effect
Randomization
Subwakefullness Syndrome
Anti-Anxiety Effect

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