PMID: 2499104Jan 1, 1989Paper

Comparative study on the expression of the blood group antigens Le a, Le b, Le x, Le y and the carbohydrate antigens CA 19-9 and CA-50 in chronic pancreatitis and pancreatic carcinoma

Virchows Archiv. A, Pathological Anatomy and Histopathology
J Schwenk, J Makovitzky

Abstract

The expression of the blood group antigens Le a, Le b, Le x, Le y and the carbohydrate antigens CA 19-9 and CA-50 was studied in 20 ductal pancreatic carcinomas, 24 pancreases with chronic pancreatitis and 10 normal fetal and adult pancreases. CA 19-9, CA-50 and Le a showed the strongest staining intensity, the highest percentage of labelled cells, and a membrane-bound expression pattern in epithelial cells of normal pancreas, chronic pancreatitis and well differentiated (G1) carcinoma; in moderately and poorly differentiated carcinomas (G2/3) it was predominantly cytoplasmic. The staining pattern of Le b and Le x was less clearly membrane-bound but varied with cytoplasmic and Golgi-located distributions in all pancreatic specimens. Le y revealed a consistent granular antigen expression in the Golgi-region of ductal epithelial, acinar and carcinoma cells. None of the antibodies allowed a morphological differentiation by their expression pattern between hyperplastic, metaplastic and dysplastic or neoplastic cells. The differences in their staining patterns were quantitative and did not allow a qualitative differentiation between chronic pancreatitis and pancreatic carcinoma. We found coexpression of Le a and Le b antigens in 46/...Continue Reading

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Citations

Jan 1, 1993·Teratogenesis, Carcinogenesis, and Mutagenesis·S CorraP M Pour
Nov 2, 2004·Virchows Archiv : an International Journal of Pathology·Matthias EvertFrank Dombrowski
Oct 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E K PhilipsenE Dabelsteen
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S KamoshidaR Y Osamura
Mar 17, 2020·Internal Medicine·Yoshinori TanakaUNKNOWN Ehime Pancreato-Cholangiology (EPOCH) Study Group

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