Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs

Veterinary Anaesthesia and Analgesia
Eduardo R MonteiroJuliany Gomes Quitzan

Abstract

To compare the effects of morphine (MOR), methadone (MET), butorphanol (BUT) and tramadol (TRA), in combination with acepromazine, on sedation, cardiorespiratory variables, body temperature and incidence of emesis in dogs. Prospective randomized, blinded, experimental trial. Six adult mixed-breed male dogs weighing 12.0 +/- 4.3 kg. Dogs received intravenous administration (IV) of acepromazine (0.05 mg kg(-1)) and 15 minutes later, one of four opioids was randomly administered IV in a cross-over design, with at least 1-week intervals. Dogs then received MOR 0.5 mg kg(-1); MET 0.5 mg kg(-1); BUT 0.15 mg kg(-1); or TRA 2.0 mg kg(-1). Indirect systolic arterial pressure (SAP), heart rate (HR), respiratory rate (f(R)), rectal temperature, pedal withdrawal reflex and sedation were evaluated at regular intervals for 90 minutes. Acepromazine administration decreased SAP, HR and temperature and produced mild sedation. All opioids further decreased temperature and MOR, BUT and TRA were associated with further decreases in HR. Tramadol decreased SAP whereas BUT decreased f(R) compared with values before opioid administration. Retching was observed in five of six dogs and vomiting occurred in one dog in MOR, but not in any dog in the remai...Continue Reading

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Citations

Jun 6, 2013·The Veterinary Record·P Muñoz-RasconR Gómez-Villamandos
Aug 13, 2015·Veterinary Anaesthesia and Analgesia·Leonardo L de CarvalhoEwaldo de Mattos-Junior
Apr 17, 2015·Veterinary Anaesthesia and Analgesia·Eduardo R MonteiroBetânia S Monteiro
Apr 2, 2013·Research in Veterinary Science·L OlsénC Ingvast-Larsson
Nov 16, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Hugo van OostromJoost J Uilenreef
Mar 2, 2010·Topics in Companion Animal Medicine·Tamara Grubb
Mar 25, 2015·Veterinary Anaesthesia and Analgesia·Zoë PuighibetIgnacio A Gómez de Segura
Apr 11, 2013·Veterinary Anaesthesia and Analgesia·Andrea SánchezFrancisco G Laredo
Oct 25, 2011·The Journal of Small Animal Practice·D Van VyncktB Van Ryssen
Apr 23, 2014·Veterinary Surgery : VS·Jennifer G CarrLaura Smith
Aug 6, 2015·Journal of the South African Veterinary Association·Jacques P FerreiraLynette Bester
Nov 14, 2012·Journal of the American Animal Hospital Association·Jennifer A GinnRebecca L Stepien
Mar 19, 2014·International Heart Journal·Adriana BanozicDamir Sapunar
Nov 17, 2020·Frontiers in Veterinary Science·Stephanie KeatingDavid J Schaeffer
Nov 28, 2020·Basic & Clinical Pharmacology & Toxicology·Freja Drost AndersenCharlotte Uggerhøj Andersen
Jan 4, 2021·Veterinary Anaesthesia and Analgesia·Julia P P RangelDaniela Campagnol
Mar 1, 2017·Veterinary Anaesthesia and Analgesia·Flavia S BittiEduardo R Monteiro
Nov 28, 2017·Veterinary Anaesthesia and Analgesia·William Jm McFadzeanHugo van Oostrom

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