Comparative Susceptibility of Aedes albopictus and Aedes aegypti to Dengue Virus Infection After Feeding on Blood of Viremic Humans: Implications for Public Health

The Journal of Infectious Diseases
James WhitehornCameron P Simmons

Abstract

Aedes albopictus is secondary to Aedes aegypti as a vector of dengue viruses (DENVs) in settings of endemicity, but it plays an important role in areas of dengue emergence. This study compared the susceptibility of these 2 species to DENV infection by performing 232 direct blood-feeding experiments on 118 viremic patients with dengue in Vietnam. Field-derived A. albopictus acquired DENV infections as readily as A. aegypti after blood feeding. Once infected, A. albopictus permitted higher concentrations of DENV RNA to accumulate in abdominal tissues, compared with A. aegypti. However, the odds of A. albopictus having infectious saliva were lower than the odds observed for A. aegypti (odds ratio, 0.70; 95% confidence interval, .52-.93). These results quantitate the susceptibility of A. albopictus to DENV infection and will assist parameterization of models for predicting disease risk in settings where A. albopictus is present.

References

Nov 1, 1979·The American Journal of Tropical Medicine and Hygiene·D J GublerJ Sulianti Saroso
Mar 1, 1989·Journal of Medical Entomology·W A HawleyG B Craig
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·R H WhiteheadP Simasathien
Mar 7, 2002·Public Health Reports·M Hugh-Jones
Oct 5, 2002·The American Journal of Tropical Medicine and Hygiene·Kristine E BennettBarry J Beaty
May 2, 2006·Journal of the American Mosquito Control Association·Roberto RomiLuciano Toma
Oct 4, 2006·BMC Microbiology·Ricardo F Mercado-CurielMaría de Lourdes Muñoz
Jan 10, 2008·JAMA : the Journal of the American Medical Association·David M Morens, Anthony S Fauci
Apr 1, 2009·Emerging Infectious Diseases·Eric M LeroyXavier De-Lamballerie
Apr 15, 2009·PLoS Neglected Tropical Diseases·Massamba SyllaWilliam C Black
Jul 11, 2009·BMC Evolutionary Biology·Louis LambrechtsThomas W Scott
Sep 4, 2009·Vector Borne and Zoonotic Diseases·Christophe PaupyFrédéric Simard
Mar 31, 2010·Emerging Infectious Diseases·Mohammad I IssackShyam S Manraj
Jun 4, 2010·PLoS Neglected Tropical Diseases·Louis LambrechtsDuane J Gubler
Jan 27, 2012·BMC Public Health·Hong-Juan PengXiao-Guang Chen
Mar 28, 2012·Vector Borne and Zoonotic Diseases·Jolyon M MedlockWim Van Bortel
Apr 13, 2012·The New England Journal of Medicine·Cameron P SimmonsBridget Wills
Aug 18, 2012·Journal of Medical Entomology·Stephanie L RichardsBarry W Alto
Dec 5, 2012·PLoS Neglected Tropical Diseases·Diego Ruiz-MorenoLaura C Harrington
Dec 5, 2012·PLoS Neglected Tropical Diseases·Marcel WolbersChristl A Donnelly
Apr 9, 2013·Nature·Samir BhattSimon I Hay
May 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Minh Nguyen NguyetCameron P Simmons
Jun 25, 2014·Parasites & Vectors·Rebecca C ChristoffersonHelen J Wearing

❮ Previous
Next ❯

Citations

Nov 21, 2015·Vaccine·Jorge E OsorioDan T Stinchcomb
Oct 20, 2015·Vaccine·Rebecca C Christofferson, Christopher N Mores
Oct 16, 2015·Vaccine·Cameron P SimmonsBridget Wills
Jun 21, 2016·EBioMedicine·Jing Liu-HelmerssonJoacim Rocklöv
Apr 6, 2016·Parasitology·Helen J WearingRebecca C Christofferson
Nov 5, 2016·Acta Tropica·André Barretto Bruno WilkeMauro Toledo Marrelli
Aug 19, 2017·The American Journal of Tropical Medicine and Hygiene·Elizabeth A DietrichClaire Y-H Huang
Dec 19, 2017·Frontiers in Microbiology·Zhuanzhuan LiuXiao-Guang Chen
Dec 7, 2017·Memórias do Instituto Oswaldo Cruz·Chelsea T SmarttBarry W Alto
Dec 29, 2017·Parasites & Vectors·Gerard TerradasElizabeth A McGraw
Jul 19, 2018·PLoS Neglected Tropical Diseases·Riccardo MorettiMaurizio Calvitti
May 12, 2020·PLoS Neglected Tropical Diseases·Amanda MurphyFrancesca D Frentiu
May 21, 2020·The American Journal of Tropical Medicine and Hygiene·Lauren B CarringtonCameron P Simmons
Mar 3, 2020·Infectious Diseases of Poverty·Ye XuXiao-Guang Chen
Jul 28, 2017·Frontiers in Cellular and Infection Microbiology·Congcong GuoGuang Yang
Jan 30, 2020·Nature Microbiology·Scott C Weaver
Jun 28, 2017·Tropical Medicine & International Health : TM & IH·Sylvia JoanneSazaly AbuBakar
Mar 30, 2017·Parasites & Vectors·Oscar Alexander Aguirre-ObandoMário Antônio Navarro-Silva
Jul 6, 2019·BMC Infectious Diseases·Gerard Terradas, Elizabeth A McGraw
Apr 12, 2020·Parasites & Vectors·Kevin K ChanSally L Paulson
Aug 11, 2017·Parasites & Vectors·Elodie CalvezMyrielle Dupont-Rouzeyrol

❮ Previous
Next ❯

Datasets Mentioned

BETA
GQ199773.1

Methods Mentioned

BETA
FCS
PCR
enzyme-linked immunosorbent assays

Software Mentioned

R
FastStart
R Foundation for Statistical
GS Mapping

Related Concepts