Abstract
Only in the last few years has non-alcoholic steatohepatitis been recognized as an important and relatively common liver disease. To date, the therapeutic options are limited, vitamin E and metformin have been proposed for the treatment of this condition, although their mechanisms are not completely clarified as yet. The aim of this study was to investigate the anti-inflammatory and anti-oxidative mechanisms of these drugs in an experimental model of non-alcoholic steatohepatitis in the young rat. Male rats, just after weaning, were divided into four groups: a control group that received a standard diet; a high fat diet group; two high fat diet fed groups treated with vitamin E or metformin, respectively. After 4 weeks, we evaluated in the liver the modification of lipid peroxidation, assessed by malondialdehyde, TNF-alpha levels, S-nitrosylated protein, inducible nitric oxide sinthase (iNOS), and peroxisome proliferators-activated receptors (PPAR) expression and metalloproteinase activity. High fat diet increased malondialdehyde, nitrotyrosilated proteins, and TNF-alpha tissue content. Moreover, a decrease of PPAR-alpha and an increase of PPAR-gamma expression were observed. An increase of metalloproteinase activity was also s...Continue Reading
References
Aug 18, 1994·Nature·G M McGeehanS Kidao
Jun 6, 2000·The Journal of Pediatrics·J E Lavine
Sep 6, 2000·Nature Medicine·H Z LinA M Diehl
Sep 25, 2001·Lancet·G MarchesiniN Melchionda
Oct 12, 2001·Biochemical and Biophysical Research Communications·N OkadaS Kubota
Nov 3, 2001·Journal of Hepatology·C LoguercioC Del Vecchio Blanco
Oct 29, 2002·The Journal of Biological Chemistry·Songtao YuJanardan K Reddy
Dec 14, 2002·Journal of Hepatology·Yoshio SumidaJunji Yodoi
Jun 14, 2003·The Journal of Biological Chemistry·Oksana GavrilovaMarc L Reitman
Sep 2, 2003·Gastroenterology·Laurie D DeleveZoltan A Tokes
Dec 17, 2003·Journal of Pediatric Gastroenterology and Nutrition·Pietro VajroFiorella Migliaro
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kittichai PromratJay H Hoofnagle
Feb 21, 2004·Biochemical and Biophysical Research Communications·Charles S LieberLeonore M DeCarli
Feb 28, 2004·Alimentary Pharmacology & Therapeutics·A UygunK Dagalp
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Priya MohantyParesh Dandona
Jul 1, 2004·Alimentary Pharmacology & Therapeutics·S NairR P Perrillo
Nov 3, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Papreddy V Kashireddy, M Sambasiva Rao
Dec 16, 2004·Pediatric Transplantation·Kerkar Nanda
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Susan E SchadingerStephen R Farmer
Apr 2, 2005·Alimentary Pharmacology & Therapeutics·J B SchwimmerJ E Lavine
Apr 22, 2005·The American Journal of Gastroenterology·Elisabetta BugianesiGiulio Marchesini
Aug 30, 2005·Biochemical and Biophysical Research Communications·Mitsutaka InoueToshikatsu Okumura
Oct 18, 2005·Alimentary Pharmacology & Therapeutics·E AlbanoM Vidali
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabetta BugianesiGiulio Marchesini
Dec 21, 2005·Journal of Hepatology·Claire Z Larter, Geoffrey C Farrell
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Geoffrey C Farrell, Claire Z Larter
Jul 4, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Glen LutchmanJay H Hoofnagle
Sep 1, 2006·Current Treatment Options in Gastroenterology·Eve A Roberts, Jason Yap
Mar 3, 2007·Alcoholism, Clinical and Experimental Research·Hideyuki KojimaYasuhiro Tamagawa
Jun 7, 2007·The New England Journal of Medicine·David M Nathan
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Glen LutchmanJay H Hoofnagle
Aug 19, 2007·Current Drug Discovery Technologies·Poonam Mishra, Zobair M Younossi
Aug 31, 2007·World Journal of Gastroenterology : WJG·Marko DuvnjakVedran Velagić
Jan 8, 2008·World Journal of Gastroenterology : WJG·Eric R KallwitzScott J Cotler
Citations
Jun 26, 2010·The Journal of Clinical Investigation·Marc ForetzBenoit Viollet
May 3, 2013·Lipids in Health and Disease·Jiqu XuFenghong Huang
Dec 12, 2012·Hepatitis Research and Treatment·Said A Al-BusafiMarc Deschenes
Jun 12, 2014·Toxicology and Applied Pharmacology·Ana Janaina Jeanine M LemosValéria Wanderley-Teixeira
Feb 21, 2016·The Journal of Nutritional Biochemistry·Paola DongiovanniLuca Valenti
Feb 5, 2011·The Journal of Nutritional Biochemistry·Anna IaconoRosaria Meli
Oct 10, 2009·British Journal of Pharmacology·C AgardP Pacaud
Nov 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Ashwani K SingalSteven A Weinman
Nov 29, 2011·Clinical Science·Benoit ViolletFabrizio Andreelli
Feb 15, 2012·International Immunopharmacology·Hongmei YuanLi Zhang
Apr 4, 2012·Free Radical Research·Mayuko MoritaEtsuo Niki
Mar 2, 2011·Journal of Hepatology·Marcos PasarínJaime Bosch
May 6, 2014·Frontiers in Immunology·Rosaria MeliAntonio Calignano
Jul 28, 2016·European Journal of Pharmacology·Grażyna WójcickaJerzy Bełtowski
Mar 25, 2017·Nutrients·Jiqu XuFenghong Huang
Dec 20, 2013·Nutrition Research and Practice·Do Yeon KimRyowon Choue
Oct 17, 2015·Nutrients·Jiqu XuFenghong Huang
Oct 30, 2016·Molecular Nutrition & Food Research·Adriano LamaRosaria Meli
Aug 30, 2012·The Open Cardiovascular Medicine Journal·Irene P TzanetakouDespina N Perrea
Jul 4, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dinesh M TripathiJuan Carlos García-Pagán
Feb 23, 2020·Journal of Lipid Research·Clinton M HasenourJamey D Young
Feb 4, 2021·Antioxidants·Johanna C Arroyave-OspinaHan Moshage
Sep 14, 2020·Redox Biology·Maren C PodszunYaron Rotman
Mar 29, 2021·Redox Biology·Maren C Podszun, Jan Frank
Mar 28, 2021·BioFactors·Jan FrankJana Golombek
Mar 21, 2013·Lipids in Health and Disease·Jiqu XuFenghong Huang