Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat

European Journal of Pharmacology
Giuseppina Mattace RasoRosaria Meli

Abstract

Only in the last few years has non-alcoholic steatohepatitis been recognized as an important and relatively common liver disease. To date, the therapeutic options are limited, vitamin E and metformin have been proposed for the treatment of this condition, although their mechanisms are not completely clarified as yet. The aim of this study was to investigate the anti-inflammatory and anti-oxidative mechanisms of these drugs in an experimental model of non-alcoholic steatohepatitis in the young rat. Male rats, just after weaning, were divided into four groups: a control group that received a standard diet; a high fat diet group; two high fat diet fed groups treated with vitamin E or metformin, respectively. After 4 weeks, we evaluated in the liver the modification of lipid peroxidation, assessed by malondialdehyde, TNF-alpha levels, S-nitrosylated protein, inducible nitric oxide sinthase (iNOS), and peroxisome proliferators-activated receptors (PPAR) expression and metalloproteinase activity. High fat diet increased malondialdehyde, nitrotyrosilated proteins, and TNF-alpha tissue content. Moreover, a decrease of PPAR-alpha and an increase of PPAR-gamma expression were observed. An increase of metalloproteinase activity was also s...Continue Reading

References

Sep 25, 2001·Lancet·G MarchesiniN Melchionda
Oct 12, 2001·Biochemical and Biophysical Research Communications·N OkadaS Kubota
Dec 17, 2003·Journal of Pediatric Gastroenterology and Nutrition·Pietro VajroFiorella Migliaro
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kittichai PromratJay H Hoofnagle
Feb 21, 2004·Biochemical and Biophysical Research Communications·Charles S LieberLeonore M DeCarli
Feb 28, 2004·Alimentary Pharmacology & Therapeutics·A UygunK Dagalp
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Priya MohantyParesh Dandona
Jul 1, 2004·Alimentary Pharmacology & Therapeutics·S NairR P Perrillo
Nov 3, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Papreddy V Kashireddy, M Sambasiva Rao
Dec 16, 2004·Pediatric Transplantation·Kerkar Nanda
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Susan E SchadingerStephen R Farmer
Apr 2, 2005·Alimentary Pharmacology & Therapeutics·J B SchwimmerJ E Lavine
Apr 22, 2005·The American Journal of Gastroenterology·Elisabetta BugianesiGiulio Marchesini
Aug 30, 2005·Biochemical and Biophysical Research Communications·Mitsutaka InoueToshikatsu Okumura
Oct 18, 2005·Alimentary Pharmacology & Therapeutics·E AlbanoM Vidali
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabetta BugianesiGiulio Marchesini
Dec 21, 2005·Journal of Hepatology·Claire Z Larter, Geoffrey C Farrell
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Geoffrey C Farrell, Claire Z Larter
Jul 4, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Glen LutchmanJay H Hoofnagle
Sep 1, 2006·Current Treatment Options in Gastroenterology·Eve A Roberts, Jason Yap
Mar 3, 2007·Alcoholism, Clinical and Experimental Research·Hideyuki KojimaYasuhiro Tamagawa
Jun 7, 2007·The New England Journal of Medicine·David M Nathan
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Glen LutchmanJay H Hoofnagle
Aug 19, 2007·Current Drug Discovery Technologies·Poonam Mishra, Zobair M Younossi
Aug 31, 2007·World Journal of Gastroenterology : WJG·Marko DuvnjakVedran Velagić
Jan 8, 2008·World Journal of Gastroenterology : WJG·Eric R KallwitzScott J Cotler

❮ Previous
Next ❯

Citations

Dec 12, 2012·Hepatitis Research and Treatment·Said A Al-BusafiMarc Deschenes
Feb 21, 2016·The Journal of Nutritional Biochemistry·Paola DongiovanniLuca Valenti
Feb 5, 2011·The Journal of Nutritional Biochemistry·Anna IaconoRosaria Meli
Nov 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Ashwani K SingalSteven A Weinman
Nov 29, 2011·Clinical Science·Benoit ViolletFabrizio Andreelli
Feb 15, 2012·International Immunopharmacology·Hongmei YuanLi Zhang
Apr 4, 2012·Free Radical Research·Mayuko MoritaEtsuo Niki
Mar 2, 2011·Journal of Hepatology·Marcos PasarínJaime Bosch
Dec 20, 2013·Nutrition Research and Practice·Do Yeon KimRyowon Choue
Aug 30, 2012·The Open Cardiovascular Medicine Journal·Irene P TzanetakouDespina N Perrea
Jul 4, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dinesh M TripathiJuan Carlos García-Pagán
Mar 29, 2021·Redox Biology·Maren C Podszun, Jan Frank

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here