Comparative Therapeutic Efficacy of (153)Sm-EDTMP and (177)Lu-EDTMP for Bone Pain Palliation in Patients with Skeletal Metastases: Patients' Pain Score Analysis and Personalized Dosimetry

Frontiers in Medicine
Sarika SharmaBhagwant Rai Mittal

Abstract

The aim of the present study was to compare the therapeutic efficacy of (153)Sm-EDTMP and (177)Lu-EDTMP in pain palliation in cancer patients with skeletal metastases. Thirty patients (25 M:5 F, mean age: 66.0 ± 14.7 years) of breast/prostate cancer with documented skeletal metastases were recruited prospectively. Twenty patients were considered randomly for treatment with (153)Sm-EDTMP and with (177)Lu-EDTMP in 10 patients, respectively. Using fixed dose of 37.0 MBq/kg body weight of each, the mean administered doses of (153)Sm-EDTMP and (177)Lu-EDTMP were 2,155.2 ± 419.6 MBq (1,347-2,857) and 1,935.1 ± 559.4 MBq (1,073-2,627), respectively. Anterior and posterior whole body images were acquired at different time points following radioactivity administration. The first data set of pre-void images (acquired at 0.5 h) representing the total activity of either of (153)Sm-EDTMP or (177)Lu-EDTMP was considered as reference images. All the serial images were used for patients' dosimetry analysis by using organ level internal dosimetry assessment algorithm. Reduction in pain scoring was assessed clinically over 8 weeks by using appropriate WHO criteria and correlated with the absorbed dose to the metastatic sites. A total of 86 metas...Continue Reading

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Citations

Feb 12, 2020·International Journal of Radiation Biology·Hesham M H ZakalyMichael Zhukovsky
Aug 19, 2020·Journal of Clinical Medicine·Reyhaneh Manafi-FaridMohsen Beheshti
Dec 2, 2020·Cancer Biotherapy & Radiopharmaceuticals·Emran AskariRamin Sadeghi
Jul 3, 2021·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Mostafa Y A MostafaM Zhukovsky
Jan 10, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·René FernándezHoracio Amaral

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