Comparative tolerability of ampicillin, amoxicillin, and trimethoprim-sulfamethoxazole suspensions in children with otitis media.

Antimicrobial Agents and Chemotherapy
H M Feder

Abstract

The tolerabilities of ampicillin, amoxicillin, and trimethoprim-sulfamethoxazole (TMP-SMX) suspensions were evaluated in 263 children with otitis media. Because of watery stools, therapy was discontinued in 6 of 83 patients treated with ampicillin, in none of 89 patients treated with amoxicillin (P less than 0.01), and in 1 of 91 patients treated with TMP-SMX (P less than 0.03). Of the patients who completed the treatment courses, 13 recipients of ampicillin suffered loose or watery stools for 4 or more days, compared with 6 of the amoxicillin recipients (P less than 0.04) and 5 of the TMP-SMX recipients (P less than 0.02). Thus, ampicillin was clearly less well tolerated than either amoxicillin or TMP-SMX.

References

Jun 1, 1974·The Journal of Infectious Diseases·V M HowieJ Sloyer
Jun 1, 1974·The Journal of Infectious Diseases·G H Aronovitx
Jun 1, 1974·The Journal of Infectious Diseases·J D Jones
May 1, 1968·American Journal of Diseases of Children·C HalstedE Wolinsky

❮ Previous
Next ❯

Citations

Jul 25, 2000·Journal of Clinical Pharmacy and Therapeutics·C L Falconer, D M Gardner
Jan 10, 2012·Expert Opinion on Drug Safety·Philippe Lagacé-Wiens, Ethan Rubinstein
Sep 1, 1988·The Journal of International Medical Research·B K BergströmG Movin

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

© 2021 Meta ULC. All rights reserved