Comparative toxic effect of the surface lipid of Corynebacterium ovis on peritoneal macrophages.

Infection and Immunity
G C Hard

Abstract

The postphagocytic effect on mouse, rabbit, and guinea pig peritoneal macrophages of a petrol-ether lipid extract from Corynebacterium ovis (C. pseudotuberculosis) representing the surface coat of the organism external to the cell wall was investigated by examing three parameters of cytotoxicity, viability assayed by dye exclusion, glycolytic activity, and ultrastructural morphology. The viability test demonstrated a lethal effect on normal and immune mouse macrophages but not on those of the rabbit or guinea pig. Measurement of glycolsis indicated a significant degree of cytotoxicity in normal mouse macrophages ingesting lipid, a nonsignificant depression of activity in cells from immune mice, and no alteration in the activities of rabbit and guinea pig macrophages. Electron microscopy demonstrated that C. ovis surface lipid caused acute lethal injury in normal and immune mouse macrophages. The early stages of degeneration were typified by dilatation of the cisternae of rough endoplasmic reticulum, Golgi lamellae, and nuclear envelope, proceeding to focal disruption of various cell membranes, particularly those of the lipidcontaining phagolysosomes and nucleus. In contrast, over the 3-h period of study, no cytotoxic change wa...Continue Reading

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Citations

Oct 27, 2004·Veterinary Dermatology·Israel YeruhamYoram Kalgard
Feb 7, 2009·Expert Review of Vaccines·Fernanda A DorellaVasco Azevedo
Dec 4, 2015·Virulence·Elena HackerAndreas Burkovski
Jun 1, 2013·ISRN Microbiology·Andreas Burkovski
Nov 30, 2011·Revista de saúde pública·Alexandre Alves de Souza de Oliveira DiasAna Luíza Mattos Guaraldi
May 10, 2017·Infection and Immunity·Judith SchickRoland Lang
Oct 1, 1991·Clinical and Experimental Immunology·J WalkerE Meeusen
May 8, 2004·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·S A Selim
Oct 28, 2017·Frontiers in Microbiology·Alberto OliveiraAlice R Wattam
Feb 7, 1998·Infection and Immunity·C P SimmonsR A Strugnell
Jan 1, 1982·Veterinary Immunology and Immunopathology·F M Collins, S G Campbell
Aug 1, 1997·Infection and Immunity·C P SimmonsR A Strugnell
Sep 11, 2007·Journal of Comparative Pathology·G J Baird, M C Fontaine
Jan 14, 2022·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Maria da Conceição Aquino de SáRoberto Meyer

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