PMID: 6539285May 1, 1984Paper

Comparative toxicities of dietary caffeine and theobromine in the rat

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
J H Gans

Abstract

Caffeine, incorporated into pulverized Purina Rat Chow at a concentration of 0.5%, was fed to male Sprague-Dawley rats for 7 or 8 wk and the effects were compared with those of 0.8% dietary theobromine, fed to male rats for 7 wk. Both dietary methylated xanthines produced significant decreases in food consumption and body-weight gain when compared to their respective control groups. Food consumption of caffeine-fed rats was 57.2% of controls and for theobromine-fed rats it was 77.9% of the respective controls. Theobromine produced significant decreases in thymus weights, with caffeine producing smaller decreases. The theobromine-fed rats showed severe testicular atrophy with extensive spermatogenic cell degeneration and necrosis, while the testes of rats fed caffeine for 7 or 8 wk showed only scattered vacuolar degeneration of spermatogenic cells. Caffeine appears to be more potent than theobromine as an anorexic agent in rats, but to be equivalent to theobromine in its potential for inducing thymic atrophy and spermatogenic cell destruction with testicular atrophy.

References

Jun 15, 1979·Toxicology and Applied Pharmacology·S M TarkaJ H Gans
Mar 1, 1967·Canadian Journal of Physiology and Pharmacology·J M Peters, E M Boyd
Sep 1, 1982·Pharmacology, Biochemistry, and Behavior·S J Cooper
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Apr 1, 1982·Toxicology and Applied Pharmacology·J H Gans
Oct 1, 1982·Pharmacology, Biochemistry, and Behavior·K MuellerW L Nyhan
Mar 30, 1981·Toxicology and Applied Pharmacology·S M TarkaJ H Gans

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Citations

Aug 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B Stavric
Jan 11, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S M TarkaC A Shively
Jan 1, 1992·Reproductive Toxicology·Y WangL D Russell
Jan 18, 2014·Reproductive Toxicology·Jodi M MaglichMathew T Pletcher
May 15, 2004·The Journal of Pharmacy and Pharmacology·Almira RamanavicieneArunas Ramanavicius
Jul 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·João P MonteiroBranca M Silva
Sep 17, 2016·Journal of Toxicology·Amy ClewellIlona Pasics Szakonyiné
Jan 27, 2016·International Journal of Toxicology·Robert W KappRichard Kraska
Apr 7, 2018·Critical Reviews in Food Science and Nutrition·João MonteiroBranca M Silva
May 10, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Omobola F OluwoleYinusa Raji
Jan 1, 1989·Toxicologic Pathology·S P Bishop
Jan 9, 2020·Journal of Toxicology·Timothy S MurbachIlona Pasics Szakonyiné
Nov 3, 2020·Journal of Animal Physiology and Animal Nutrition·Carmen KleinBritta Dobenecker
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wiem Haj AhmedChristian Carpéné

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