Comparative toxicity of polychlorinated biphenyls to Japanese quail (Coturnix c. japonica) and American kestrels (Falco sparverius)

Journal of Toxicology and Environmental Health
J E ElliottA Lorenzen

Abstract

Polychlorinated biphenyls (PCBs) and related halogenated hydrocarbons bioaccumulate to high concentrations in top predators, such as raptorial birds, yet little is known of PCB toxicity to such species. This study explored several aspects of both the acute and chronic response of American kestrels (Falco sparverius) to three purified PCB congeners and a commercial mixture, Aroclor 1254, and compared the response to that of the Japanese quail (Coturnix c. japonica), a more studied species known to be PCB sensitive. In one experiment, adult female birds were given single oral doses of either Aroclor 1254, 3,3',4,4'-TCB (PCB 77, IUPAC nomenclature), 3,3',4,4',5-PCB (PCB 126) or 2,2',4,4',5,5'-HCB (PCB 153) and sacrificed after 5 d. In kestrels, neither the pure compounds nor the mixture affected hepatic or renal porphyrin levels. There was slight but significant hepatic and renal ethoxyresorufin O-deethylase (EROD) induction in birds dosed with PCBs 77 and 126. A cytochrome P-4501A (CYP1A) cross-reactive protein was detected in liver and kidney of kestrels given PCBs 77 and 126, but not in Aroclor 1254-dosed birds. In quail, an acute dose of Aroclor 1254 caused significant liver weight increases, hepatic and renal EROD and aminopy...Continue Reading

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Citations

Apr 27, 2013·Archives of Environmental Contamination and Toxicology·I de la Casa-ResinoM Pérez-López
Jul 28, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Mary Ann Ottinger, Karen M Dean
Jun 19, 2004·Journal of Toxicology and Environmental Health. Part a·Jan LycheErik Ropstad
Aug 10, 2007·Journal of Toxicology and Environmental Health. Part a·Glen A FoxKeith A Grasman
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·John M BrauschPhilip N Smith
Feb 12, 2002·Neurotoxicology and Teratology·Mary Ann OttingerNichola Thompson
Jan 14, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M H BoilyP A Spear

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