PMID: 11912057Mar 26, 2002Paper

Comparative toxinological and immunological studies on the nematocyst venoms of the Red Sea fire corals Millepora dichotoma and M. platyphylla

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
F F Radwan

Abstract

A method appropriate for isolating of fire coral nematocysts of Millepora dichotoma (Md) and Millepora platyphylla (Mp) was described and compared with techniques that had been used before. Isolated nematocyst venoms of Md (Md-TX) and Mp (Mp-TX) were lethal to mice (had LD50 values of 0.51 and 0.21 microg/g mouse body, respectively) and displayed variable hemolytic, vasopermeable and dermonecrotic properties. The potent hemolysins of Md-TX and Mp-TX, which purified by gel filtration chromatography, possessed prominent proteins of molecular weights 35 and 31 kDa and had LD50 values 0.35 and 0.25 microg/g mouse, respectively. Hemolytic activities of crude venoms and their fraction could be inactivated using known anti-hemolytic agents. Both Md-TX and Mp-TX had distinguishable antigenic properties and their antisera raised in immunized mice and stung human were cross-reactive. ELISA assays showed an antigenic similarity among the studied fire coral homologous cytolytic counterparts.

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Feb 13, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·F F Radwan, J W Burnett

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Citations

Dec 2, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Alejandro García-ArredondoJudith Sanchez-Rodriguez
Jul 24, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·César Ibarra-AlvaradoEdgar P Heimer de la Cotera
Feb 3, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Faisal F Y Radwan, Hosney M Aboul-Dahab
Nov 7, 2007·Biochemical and Biophysical Research Communications·Akiko IguchiHiroshi Nagai
Sep 29, 2015·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Rosalina Hernández-MatehualaManuel Aguilar
Jan 13, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Alejandro García-ArredondoMartín García-Servín
Dec 13, 2016·Toxins·Jason Macrander, Marymegan Daly

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