Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes

Developmental Biology
Shu-Ye JiangSrinivasan Ramachandran

Abstract

The GRAM domain was found in glucosyltransferases, myotubularins and other membrane-associated proteins. So far, functions for majority of these proteins are yet to be uncovered. In order to address the evolutionary and functional significance of this family members, we have performed a comprehensive investigation on their genome-wide identification, phylogenetic relationship and expression divergence in five different organisms representing monocot/dicot plants, vertebrate/invertebrate animals and yeast, namely, Oryza sativa, Arabidopsis thaliana, Mus musculus, Drosophila melanogaster and Saccharomyces cerevisiae, respectively. We have identified 65 members of GRAM domain family from these organisms. Our data revealed that this family was an ancient group and various organisms had evolved into different family sizes. Large-scale genome duplication and divergence in both expression patterns and functions were significantly contributed to the expansion and retention of this family. Mouse and Drosophila members showed higher divergences in their proteins as indicated by higher Ka/Ks ratios and possessed multiple domains in various combinations. However, in plants, their protein functions were possibly retained with a relatively l...Continue Reading

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Citations

Apr 29, 2014·Plant Science : an International Journal of Experimental Plant Biology·Kevin N BaronClaudio Stasolla
May 5, 2010·International Journal of Biological Sciences·Shu-Ye Jiang, Srinivasan Ramachandran
Dec 21, 2010·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Yunhua ChiShu-Ye Jiang
Apr 25, 2012·Plant Science : an International Journal of Experimental Plant Biology·Kevin N BaronClaudio Stasolla
Dec 1, 2015·Scientific Reports·Shu-Ye JiangSrinivasan Ramachandran
Mar 5, 2016·Scientific Reports·Nuria MauriCrisanto Gutierrez
Apr 17, 2008·Plant & Cell Physiology·Rengasamy RamamoorthySrinivasan Ramachandran
Jun 2, 2020·Molecular Biology Reports·Weiwei WangFengli Sun
Jun 24, 2018·Scientific Reports·Puja KhannaGyeong Hun Baeg

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