Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis

Fluids and Barriers of the CNS
Edward StopaConrad Johanson

Abstract

In Alzheimer's disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression at the blood-cerebrospinal fluid barrier could provide further insight into the epithelial and stromal responses to neurodegenerative disease states. Transcriptome-wide Affymetrix microarrays were used to determine disease-related changes in gene expression in human CP. RNA from post-mortem samples of the entire lateral ventricular choroid plexus was extracted from 6 healthy controls (Ctrl), 7 patients with advanced (Braak and Braak stage III-VI) Alzheimer's disease (AD), 4 with frontotemporal dementia (FTD) and 3 with Huntington's disease (HuD). Statistics and agglomerative clustering were accomplished with MathWorks, MatLab; and gene set annotations by comparing input sets to GeneGo ( http://www.genego.com ) and Ingenuity ( http://www.ingenuity.com ) pathway sets. Bonferroni-corrected hypergeometric p-values of < 0.1 were considered a significant overlap between sets. Pronounced differences in gene expression occurred in CP of advanced AD patients vs. Ctrls. Metabolic and immune-related pathways including acute phase response, cytokine, cell adhesion, interferons, and JA...Continue Reading

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Citations

Dec 14, 2018·Fluids and Barriers of the CNS·Shawn KantGerald D Silverberg
Feb 6, 2019·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
Mar 21, 2020·International Journal of Molecular Sciences·Jose A SantiagoJudith A Potashkin
May 8, 2020·Fluids and Barriers of the CNS·Peter SolárMarek Joukal
Jun 27, 2020·Acta Neuropathologica Communications·J SaulN Bakkar
Aug 20, 2020·Fluids and Barriers of the CNS·David M F FranciscoRémy Bruggmann
Mar 21, 2020·Acta Neuropathologica Communications·Sabela Rodríguez-LorenzoHelga E de Vries
Mar 7, 2020·Fluids and Barriers of the CNS·Richard F KeepLester R Drewes
Dec 28, 2019·Brain, Behavior, and Immunity·Annina SeilerChristopher P Fagundes
Feb 13, 2021·GeroScience·Ana TahiraJoana Almeida Palha
Aug 5, 2020·Biochimica Et Biophysica Acta. Biomembranes·Ingrid KratzerHelen Stolp
Nov 2, 2021·Bioengineered·You WuYaping Zhu

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Datasets Mentioned

BETA
GPL
10379

Methods Mentioned

BETA
RNA Assay
PCR

Software Mentioned

Ingenuity
Affymetrix
MathWorks MatLab
GeneGo

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