Comparative treatment of experimental Staphylococcus aureus endophthalmitis

American Journal of Ophthalmology
H E AguilarS Gardner

Abstract

To compare treatment strategies for Staphylococcus aureus endophthalmitis, we created an animal model in an aphakic rabbit eye and tested six different approaches to treatment. Rabbit eyes were rendered aphakic, and three weeks postoperatively, S. aureus organisms were injected into the vitreous cavity. One group was maintained as a control. Twenty-four hours after bacterial injection, six different treatment groups were created for comparison. Clinical inflammation scores, culture results 48 hours after treatment, histopathologic gradings, and development of total corneal opacity three weeks after treatment were assessed. Injection of vancomycin hydrochloride into the vitreous cavity was more effective than injection of cefazolin sodium (P = .01) in reducing the percentage of eyes that had positive culture results and also resulted in lower inflammation scores. Vitrectomy plus injection of either antibiotic was more effective than injection of the same antibiotic alone in reducing culture-positive results and reducing clinical inflammation scores. addition of systemic corticosteroids to intravitreal antibiotic injection did not improve any measure of outcome. Vitrectomy and injection of intravitreal vancomycin was the most eff...Continue Reading

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Citations

Jan 10, 2002·Clinical Microbiology Reviews·Michelle C CalleganMichael S Gilmore
Feb 14, 2018·International Journal of Molecular Sciences·Seoh Wei TehSuresh Kumar Subbiah
Aug 13, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yildirim Bayezit SakalarMustafa Kemal Celen
Feb 27, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·M O YoshizumiB Mondino
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Jan 10, 2001·Current Opinion in Ophthalmology·P Montan
Dec 23, 1998·Survey of Ophthalmology·M S KresloffM A Zarbin

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